Multifunctional Complexes Based on Photoluminescent Upconversion Nanoparticles for Theranostics of the HER2-Positive Tumors

E. L. Guryev, A. S. Smyshlyaeva, N. Yu Shilyagina, S. Shanwar, A. B. Kostyuk, A. A. Shulga, E. V. Konovalova, A. V. Zvyagin, S. M. Deyev, R. V. Petrov

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches to the treatment of cancer. The opportunity to combine diagnostics and therapy appeared with the development of nanobiotechnologies and was realized in the concept of theranostics. To date, a number of promising agents based on nanomaterials capable of diagnosing, targeted therapeutic effects, and monitoring the response of tumor cells were obtained within the approach of theranostics. In this work, a new type of theranostic complexes based on upconversion nanoparticles coated with polyethylene glycol and functionalized with the DARPin–LoPE recombinant targeted toxin was developed. Selective binding of complexes to human breast adenocarcinoma cells overexpressing the HER2 receptor and specific toxicity to them were shown.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalDoklady Biochemistry and Biophysics
Volume491
Issue number1
DOIs
Publication statusPublished - 1 Mar 2020
Externally publishedYes

Keywords

  • HER2 receptor
  • nanoparticles
  • targeted therapy
  • theranostics
  • upconversion nanoparticles

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Chemistry(all)

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