Multicenterevaluierung unterschiedlicher Zielvolumenkonzepte für pädiatrische Hodgkin-Erkrankungen: Eine Fallstudie

Translated title of the contribution: Multicenter evaluation of different target volume delineation concepts in pediatric Hodgkin's lymphoma: A case study

C. Lütgendorf-Caucig, I. Fotina, E. Gallop-Evans, L. Claude, J. Lindh, T. Pelz, B. Knäusl, D. Georg, R. Pötter, K. Dieckmann

Research output: Contribution to journalArticle

12 Citations (Scopus)


Background and purpose: In pediatric Hodgkin's lymphoma (PHL) improvements in imaging and multiagent chemotherapy have allowed for a reduction in target volume. The involved-node (IN) concept is being tested in several treatment regimens for adult Hodgkin's lymphoma. So far there is no consensus on the definition of the IN. To improve the reproducibility of the IN, we tested a new involved-node-level (INL) concept, using defined anatomical boundaries as basis for target delineation. The aim was to evaluate the feasibility of IN and INL concepts for PHL in terms of interobserver variability. Patients and methods: The INL concept was defined for the neck and mediastinum by the PHL Radiotherapy Group based on accepted concepts for solid tumors. Seven radiation oncologists from six European centers contoured neck and mediastinal clinical target volumes (CTVs) of 2 patients according to the IN and the new INL concepts. The median CTVs, coefficient of variation (COV), and general conformity index (CI) were assessed. The intraclass correlation coefficient (ICC) for reliability of delineations was calculated. Results: All observers agreed that INL is a feasible and practicable delineation concept resulting in stronger interobserver concordance than the IN (mediastinum CIINL = 0.39 vs. CI IN = 0.28, neck left CIINL = 0.33; CIIN = 0.18; neck right CIINL = 0.24, CIIN = 0.14). The COV showed less dispersion and the ICC indicated higher reliability of contouring for INL (ICCINL = 0.62, p < 0.05) as for IN (ICCIN = 0.40, p < 0.05). Conclusion: INL is a practical and feasible alternative to IN resulting in more homogeneous target delineation, and it should be therefore considered as a future target volume concept in PHL.

Original languageGerman
Pages (from-to)1025-1030
Number of pages6
JournalStrahlentherapie und Onkologie
Issue number11
Publication statusPublished - Nov 2012
Externally publishedYes



  • Interobserver variability
  • Involved-node radiotherapy
  • Involved-node-level radiotherapy
  • Pediatric Hodgkin's lymphoma
  • Target volume delineation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Lütgendorf-Caucig, C., Fotina, I., Gallop-Evans, E., Claude, L., Lindh, J., Pelz, T., ... Dieckmann, K. (2012). Multicenterevaluierung unterschiedlicher Zielvolumenkonzepte für pädiatrische Hodgkin-Erkrankungen: Eine Fallstudie. Strahlentherapie und Onkologie, 188(11), 1025-1030.