Morphological assessment of influence of carbon nanofibers on digestive organs of wistar rats upon oral administration

Kirill Sergeevich Golokhvast, Nina Valentinovna Sayapina, Tatyana Anatolievna Batalova, Alexander Alexandrovich Sergievich, Ilya Vladimirovich Mishakov, Alexey Anatolievich Vedyagin, Mikhail Alexandrovich Novikov, Alexander Ivanovich Agoshkov, Valery Ivanovich Petukhov, Vladimir Alexandrovich Drozd, Sergey Maksimovich Ugay, Vladimir Viktorovich Chaika

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The results of research on three types of carbon nanofibers influence on an organism of Wistar rats at oral introduction with food in a dose of 500 mg per kilogram of a body weight within 14 days are presented. According to the results of electronic microscopy, carbon nanofibers had the following linear sizes: an average diameter is 85 nm and a length is about 5-50 μm. The influence of nanofibers on a histologic structure of stomach, intestines, and liver of rats is shown. The response to mechanical irritation is noted in signs as follows: raised mucus production, mucosal thickening, lymphoid follicles enlargement, vacuolation and necrosis in some cases.

Original languageEnglish
Article numberBM-075-15
JournalBiology and Medicine
Volume7
Issue number2
Publication statusPublished - 2015
Externally publishedYes

    Fingerprint

Keywords

  • Carbon nanofibers
  • Toxicity
  • Wistar rats

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Golokhvast, K. S., Sayapina, N. V., Batalova, T. A., Sergievich, A. A., Mishakov, I. V., Vedyagin, A. A., ... Chaika, V. V. (2015). Morphological assessment of influence of carbon nanofibers on digestive organs of wistar rats upon oral administration. Biology and Medicine, 7(2), [BM-075-15].