Morphological assessment of influence of carbon nanofibers on digestive organs of wistar rats upon oral administration

Kirill Sergeevich Golokhvast, Nina Valentinovna Sayapina, Tatyana Anatolievna Batalova, Alexander Alexandrovich Sergievich, Ilya Vladimirovich Mishakov, Alexey Anatolievich Vedyagin, Mikhail Alexandrovich Novikov, Alexander Ivanovich Agoshkov, Valery Ivanovich Petukhov, Vladimir Alexandrovich Drozd, Sergey Maksimovich Ugay, Vladimir Viktorovich Chaika

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Abstract

The results of research on three types of carbon nanofibers influence on an organism of Wistar rats at oral introduction with food in a dose of 500 mg per kilogram of a body weight within 14 days are presented. According to the results of electronic microscopy, carbon nanofibers had the following linear sizes: an average diameter is 85 nm and a length is about 5-50 μm. The influence of nanofibers on a histologic structure of stomach, intestines, and liver of rats is shown. The response to mechanical irritation is noted in signs as follows: raised mucus production, mucosal thickening, lymphoid follicles enlargement, vacuolation and necrosis in some cases.

Original language	English
Article number	BM-075-15
Journal	Biology and Medicine
Volume	7
Issue number	2
Publication status	Published - 2015
Externally published	Yes

Keywords

Carbon nanofibers
Toxicity
Wistar rats

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Golokhvast, K. S., Sayapina, N. V., Batalova, T. A., Sergievich, A. A., Mishakov, I. V., Vedyagin, A. A., Novikov, M. A., Agoshkov, A. I., Petukhov, V. I., Drozd, V. A., Ugay, S. M., & Chaika, V. V. (2015). Morphological assessment of influence of carbon nanofibers on digestive organs of wistar rats upon oral administration. Biology and Medicine, 7(2), [BM-075-15].

Morphological assessment of influence of carbon nanofibers on digestive organs of wistar rats upon oral administration. / Golokhvast, Kirill Sergeevich; Sayapina, Nina Valentinovna; Batalova, Tatyana Anatolievna; Sergievich, Alexander Alexandrovich; Mishakov, Ilya Vladimirovich ; Vedyagin, Alexey Anatolievich; Novikov, Mikhail Alexandrovich; Agoshkov, Alexander Ivanovich; Petukhov, Valery Ivanovich; Drozd, Vladimir Alexandrovich; Ugay, Sergey Maksimovich; Chaika, Vladimir Viktorovich.

In: Biology and Medicine, Vol. 7, No. 2, BM-075-15, 2015.

Research output: Contribution to journal › Article

Golokhvast, Kirill Sergeevich ; Sayapina, Nina Valentinovna ; Batalova, Tatyana Anatolievna ; Sergievich, Alexander Alexandrovich ; Mishakov, Ilya Vladimirovich ; Vedyagin, Alexey Anatolievich ; Novikov, Mikhail Alexandrovich ; Agoshkov, Alexander Ivanovich ; Petukhov, Valery Ivanovich ; Drozd, Vladimir Alexandrovich ; Ugay, Sergey Maksimovich ; Chaika, Vladimir Viktorovich. / Morphological assessment of influence of carbon nanofibers on digestive organs of wistar rats upon oral administration. In: Biology and Medicine. 2015 ; Vol. 7, No. 2.

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