Abstract
Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.
Original language | English |
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Pages (from-to) | 43-66 |
Number of pages | 24 |
Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
Volume | 77 |
Issue number | 9 |
Publication status | Published - 2014 |
Externally published | Yes |
Keywords
- Bisphosphonates
- Osteoblasts
- Osteoclasts
- Strontium ranelate
ASJC Scopus subject areas
- Pharmacology
- Toxicology