Abstract
Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.
| Original language | English |
|---|---|
| Pages (from-to) | 43-66 |
| Number of pages | 24 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 77 |
| Issue number | 9 |
| Publication status | Published - 2014 |
| Externally published | Yes |
Keywords
- Bisphosphonates
- Osteoblasts
- Osteoclasts
- Strontium ranelate
ASJC Scopus subject areas
- Pharmacology
- Toxicology
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Cite this
Vengerovskii, A. I., Khlusov, IA., & Nechaev, K. A. (2014). Molecular mechanisms of action of bisphosphonates and strontium ranelate. Eksperimental'naya i Klinicheskaya Farmakologiya, 77(9), 43-66.