Molecular mechanisms of action of bisphosphonates and strontium ranelate

A. I. Vengerovskii, Igor Albertovich Khlusov, K. A. Nechaev

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.

Original languageEnglish
Pages (from-to)43-66
Number of pages24
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume77
Issue number9
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Bisphosphonates
  • Osteoblasts
  • Osteoclasts
  • Strontium ranelate

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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