Abstract
Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.
| Original language | English |
|---|---|
| Pages (from-to) | 43-66 |
| Number of pages | 24 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 77 |
| Issue number | 9 |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Bisphosphonates
- Osteoblasts
- Osteoclasts
- Strontium ranelate
ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Molecular mechanisms of action of bisphosphonates and strontium ranelate. / Vengerovskii, A. I.; Khlusov, Igor Albertovich; Nechaev, K. A.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 77, No. 9, 2014, p. 43-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular mechanisms of action of bisphosphonates and strontium ranelate
AU - Vengerovskii, A. I.
AU - Khlusov, Igor Albertovich
AU - Nechaev, K. A.
PY - 2014
Y1 - 2014
N2 - Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.
AB - Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.
KW - Bisphosphonates
KW - Osteoblasts
KW - Osteoclasts
KW - Strontium ranelate
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UR - http://www.scopus.com/inward/citedby.url?scp=84923522109&partnerID=8YFLogxK
M3 - Article
VL - 77
SP - 43
EP - 66
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 9
ER -