Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside

N. F. Avrova, V. P. Ivanova, V. A. Tyurin, I. A. Gamalei, I. V. Klyubin, I. A. Shchepetkin, E. V. Borunov, Yu Yu Tyurina

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Abstract

It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10-11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10-8 M PMA in mouse macrophages in comparison with the effect of PMA alone.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume117
Issue number1
DOIs
Publication statusPublished - Jan 1994
Externally publishedYes

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Keywords

  • gangliosides
  • oxidative burst
  • phagocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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