Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside

N. F. Avrova, V. P. Ivanova, V. A. Tyurin, I. A. Gamalei, I. V. Klyubin, I. A. Shchepetkin, E. V. Borunov, Yu Yu Tyurina

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10-11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10-8 M PMA in mouse macrophages in comparison with the effect of PMA alone.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume117
Issue number1
DOIs
Publication statusPublished - Jan 1994
Externally publishedYes

Fingerprint

G(M1) Ganglioside
Respiratory Burst
Macrophages
Acetates
Neutrophils
Modulation
Luminol
Chemiluminescence
Peritoneal Macrophages
Luminescence
Reactive Oxygen Species
Oxygen
phorbol-12-myristate

Keywords

  • gangliosides
  • oxidative burst
  • phagocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside. / Avrova, N. F.; Ivanova, V. P.; Tyurin, V. A.; Gamalei, I. A.; Klyubin, I. V.; Shchepetkin, I. A.; Borunov, E. V.; Tyurina, Yu Yu.

In: Bulletin of Experimental Biology and Medicine, Vol. 117, No. 1, 01.1994, p. 45-47.

Research output: Contribution to journalArticle

Avrova, N. F. ; Ivanova, V. P. ; Tyurin, V. A. ; Gamalei, I. A. ; Klyubin, I. V. ; Shchepetkin, I. A. ; Borunov, E. V. ; Tyurina, Yu Yu. / Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside. In: Bulletin of Experimental Biology and Medicine. 1994 ; Vol. 117, No. 1. pp. 45-47.
@article{1309dc431df24e7e92f1b8ae1d4b024f,
title = "Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside",
abstract = "It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10-11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10-8 M PMA in mouse macrophages in comparison with the effect of PMA alone.",
keywords = "gangliosides, oxidative burst, phagocytes",
author = "Avrova, {N. F.} and Ivanova, {V. P.} and Tyurin, {V. A.} and Gamalei, {I. A.} and Klyubin, {I. V.} and Shchepetkin, {I. A.} and Borunov, {E. V.} and Tyurina, {Yu Yu}",
year = "1994",
month = "1",
doi = "10.1007/BF02444077",
language = "English",
volume = "117",
pages = "45--47",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside

AU - Avrova, N. F.

AU - Ivanova, V. P.

AU - Tyurin, V. A.

AU - Gamalei, I. A.

AU - Klyubin, I. V.

AU - Shchepetkin, I. A.

AU - Borunov, E. V.

AU - Tyurina, Yu Yu

PY - 1994/1

Y1 - 1994/1

N2 - It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10-11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10-8 M PMA in mouse macrophages in comparison with the effect of PMA alone.

AB - It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10-11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10-8 M PMA in mouse macrophages in comparison with the effect of PMA alone.

KW - gangliosides

KW - oxidative burst

KW - phagocytes

UR - http://www.scopus.com/inward/record.url?scp=51649144305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649144305&partnerID=8YFLogxK

U2 - 10.1007/BF02444077

DO - 10.1007/BF02444077

M3 - Article

VL - 117

SP - 45

EP - 47

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -