It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10-11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10-8 M PMA in mouse macrophages in comparison with the effect of PMA alone.
- oxidative burst
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)