Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro

Igor Albertovich Khlusov, N. V. Ryazantseva, A. I. Vengerovskii, K. A. Nechaev, V. D. Yakushina, M. V. Dvornichenko, Yu P. Sharkeev, E. V. Legostayeva, V. V. Novitskii

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Abstract

Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes in vitro. Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume157
Issue number2
DOIs
Publication statusPublished - Jun 2014

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Keywords

  • Apoptosis
  • Flow cytofluorometry
  • Necrosis
  • Rat myelokaryocytes
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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