Modified DTPA molecule-based nanocolloid radiopharmaceuticals

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The researches 99mTc recovery process at presence of divalent Sn(II) were made to determine necessary and sufficient amount of Sn(II), which would provide its full reducibleness in the reaction mixture. That the solution of 99mTc eluate reacts directly with the solution of modified DTPA and SnCl2 the content of radiochemical impurity (RCI) of the unreduced 99mTc(VII) in the labeled nanocolloid is 2.7 %, while the yield of the nanocolloid with the size of 100 nm is approximately 80 %. The results of researches prove the nanocolloid actively gets into the lymphatic system after injection, thus indicating its functional usefulness.

Original languageEnglish
JournalJournal of Radioanalytical and Nuclear Chemistry
DOIs
Publication statusAccepted/In press - 24 Sep 2014

Fingerprint

Pentetic Acid
Radiopharmaceuticals
Lymphatic System
Molecules
Research
Impurities
Recovery
Injections

Keywords

  • Biopsy
  • DTPA
  • Nanocolloid materials
  • Pharmaceutical
  • Radiochemical

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Health, Toxicology and Mutagenesis
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Modified DTPA molecule-based nanocolloid radiopharmaceuticals",
abstract = "The researches 99mTc recovery process at presence of divalent Sn(II) were made to determine necessary and sufficient amount of Sn(II), which would provide its full reducibleness in the reaction mixture. That the solution of 99mTc eluate reacts directly with the solution of modified DTPA and SnCl2 the content of radiochemical impurity (RCI) of the unreduced 99mTc(VII) in the labeled nanocolloid is 2.7 {\%}, while the yield of the nanocolloid with the size of 100 nm is approximately 80 {\%}. The results of researches prove the nanocolloid actively gets into the lymphatic system after injection, thus indicating its functional usefulness.",
keywords = "Biopsy, DTPA, Nanocolloid materials, Pharmaceutical, Radiochemical",
author = "Rogov, {Alexander S.} and Skuridin, {Viktor S.} and Elena Sergeevna Stasyuk and Natalia Valerievna Varlamova and Nestwrov, {Evgeny A.} and Vladimir Leonidovich Sadkin and Ilina, {Ekaterina A.}",
year = "2014",
month = "9",
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doi = "10.1007/s10967-014-3628-6",
language = "English",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
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T1 - Modified DTPA molecule-based nanocolloid radiopharmaceuticals

AU - Rogov, Alexander S.

AU - Skuridin, Viktor S.

AU - Stasyuk, Elena Sergeevna

AU - Varlamova, Natalia Valerievna

AU - Nestwrov, Evgeny A.

AU - Sadkin, Vladimir Leonidovich

AU - Ilina, Ekaterina A.

PY - 2014/9/24

Y1 - 2014/9/24

N2 - The researches 99mTc recovery process at presence of divalent Sn(II) were made to determine necessary and sufficient amount of Sn(II), which would provide its full reducibleness in the reaction mixture. That the solution of 99mTc eluate reacts directly with the solution of modified DTPA and SnCl2 the content of radiochemical impurity (RCI) of the unreduced 99mTc(VII) in the labeled nanocolloid is 2.7 %, while the yield of the nanocolloid with the size of 100 nm is approximately 80 %. The results of researches prove the nanocolloid actively gets into the lymphatic system after injection, thus indicating its functional usefulness.

AB - The researches 99mTc recovery process at presence of divalent Sn(II) were made to determine necessary and sufficient amount of Sn(II), which would provide its full reducibleness in the reaction mixture. That the solution of 99mTc eluate reacts directly with the solution of modified DTPA and SnCl2 the content of radiochemical impurity (RCI) of the unreduced 99mTc(VII) in the labeled nanocolloid is 2.7 %, while the yield of the nanocolloid with the size of 100 nm is approximately 80 %. The results of researches prove the nanocolloid actively gets into the lymphatic system after injection, thus indicating its functional usefulness.

KW - Biopsy

KW - DTPA

KW - Nanocolloid materials

KW - Pharmaceutical

KW - Radiochemical

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