Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva, E. P. Fedorova, A. M. Gur’ev, M. V. Belousov

Research output: Contribution to journalArticle

Abstract

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

Original languageEnglish
JournalBulletin of Experimental Biology and Medicine
DOIs
Publication statusAccepted/In press - 1 Jan 2018

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Keywords

  • mice
  • myelotoxicity
  • Neupogen
  • polychemotherapy
  • polysaccharides

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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