Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva, E. P. Fedorova, A. M. Gur’ev, M. V. Belousov

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

Original language	English
Journal	Bulletin of Experimental Biology and Medicine
DOIs	https://doi.org/10.1007/s10517-018-4313-5
Publication status	Accepted/In press - 1 Jan 2018

Fingerprint

Tussilago

Combination Drug Therapy

Polysaccharides

Lewis Lung Carcinoma

Paclitaxel

Neutropenia

Cisplatin

Experiments

Therapeutics

Keywords

mice
myelotoxicity
Neupogen
polychemotherapy
polysaccharides

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Safonova, E. A., Lopatina, K. A., Razina, T. G., Zueva, E. P., Fedorova, E. P., Gur’ev, A. M., & Belousov, M. V. (Accepted/In press). Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L. Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-018-4313-5

Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L. / Safonova, E. A.; Lopatina, K. A.; Razina, T. G.; Zueva, E. P.; Fedorova, E. P.; Gur’ev, A. M.; Belousov, M. V.

In: Bulletin of Experimental Biology and Medicine, 01.01.2018.

Research output: Contribution to journal › Article

Safonova, EA, Lopatina, KA, Razina, TG, Zueva, EP, Fedorova, EP, Gur’ev, AM & Belousov, MV 2018, 'Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.', Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-018-4313-5

Safonova EA, Lopatina KA, Razina TG, Zueva EP, Fedorova EP, Gur’ev AM et al. Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L. Bulletin of Experimental Biology and Medicine. 2018 Jan 1. https://doi.org/10.1007/s10517-018-4313-5

Safonova, E. A. ; Lopatina, K. A. ; Razina, T. G. ; Zueva, E. P. ; Fedorova, E. P. ; Gur’ev, A. M. ; Belousov, M. V. / Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L. In: Bulletin of Experimental Biology and Medicine. 2018.

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Access to Document

10.1007/s10517-018-4313-5