Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva, E. P. Fedorova, A. M. Gur’ev, M. V. Belousov

Research output: Contribution to journalArticle

Abstract

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

Original languageEnglish
JournalBulletin of Experimental Biology and Medicine
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Tussilago
Combination Drug Therapy
Polysaccharides
Lewis Lung Carcinoma
Paclitaxel
Neutropenia
Cisplatin
Experiments
Therapeutics

Keywords

  • mice
  • myelotoxicity
  • Neupogen
  • polychemotherapy
  • polysaccharides

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L. / Safonova, E. A.; Lopatina, K. A.; Razina, T. G.; Zueva, E. P.; Fedorova, E. P.; Gur’ev, A. M.; Belousov, M. V.

In: Bulletin of Experimental Biology and Medicine, 01.01.2018.

Research output: Contribution to journalArticle

@article{726334793dc449b7a1ae9976fc124eea,
title = "Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.",
abstract = "The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.",
keywords = "mice, myelotoxicity, Neupogen, polychemotherapy, polysaccharides",
author = "Safonova, {E. A.} and Lopatina, {K. A.} and Razina, {T. G.} and Zueva, {E. P.} and Fedorova, {E. P.} and Gur’ev, {A. M.} and Belousov, {M. V.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s10517-018-4313-5",
language = "English",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",

}

TY - JOUR

T1 - Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

AU - Safonova, E. A.

AU - Lopatina, K. A.

AU - Razina, T. G.

AU - Zueva, E. P.

AU - Fedorova, E. P.

AU - Gur’ev, A. M.

AU - Belousov, M. V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

AB - The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

KW - mice

KW - myelotoxicity

KW - Neupogen

KW - polychemotherapy

KW - polysaccharides

UR - http://www.scopus.com/inward/record.url?scp=85057574079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057574079&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4313-5

DO - 10.1007/s10517-018-4313-5

M3 - Article

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

ER -