Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva, E. P. Fedorova, A. M. Gur’ev, M. V. Belousov

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

Original language	English
Journal	Bulletin of Experimental Biology and Medicine
DOIs	https://doi.org/10.1007/s10517-018-4313-5
Publication status	Accepted/In press - 1 Jan 2018

Keywords

mice
myelotoxicity
Neupogen
polychemotherapy
polysaccharides

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/s10517-018-4313-5

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title = "Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.",

abstract = "The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.",

keywords = "mice, myelotoxicity, Neupogen, polychemotherapy, polysaccharides",

author = "Safonova, {E. A.} and Lopatina, {K. A.} and Razina, {T. G.} and Zueva, {E. P.} and Fedorova, {E. P.} and Gur{\textquoteright}ev, {A. M.} and Belousov, {M. V.}",

year = "2018",

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doi = "10.1007/s10517-018-4313-5",

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T1 - Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

AU - Safonova, E. A.

AU - Lopatina, K. A.

AU - Razina, T. G.

AU - Zueva, E. P.

AU - Fedorova, E. P.

AU - Gur’ev, A. M.

AU - Belousov, M. V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

AB - The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

KW - mice

KW - myelotoxicity

KW - Neupogen

KW - polychemotherapy

KW - polysaccharides

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