Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility

S. I. Tverdokhlebov, E. N. Bolbasov, E. V. Shesterikov, L. V. Antonova, A. S. Golovkin, V. G. Matveeva, Danila Gennadievich Petlin, Y. G. Anissimov

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22 Citations (Scopus)

Abstract

Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalApplied Surface Science
Volume329
DOIs
Publication statusPublished - 28 Feb 2015

Fingerprint

Sputter deposition
Durapatite
Biocompatibility
Hydroxyapatite
Plasmas
Acids
Surface morphology
Surface treatment
Crystallization
X ray spectroscopy
Phosphorus
Sputtering
Toxicity
Infrared spectroscopy
Calcium
Atomic force microscopy
Bone
poly(lactic acid)
Ions
Oxygen

Keywords

  • Biocompatibility
  • Biomaterial
  • Calcium-phosphate
  • Magnetron sputter deposition
  • Polylactic acid

ASJC Scopus subject areas

  • Surfaces, Coatings and Films

Cite this

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title = "Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility",
abstract = "Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.",
keywords = "Biocompatibility, Biomaterial, Calcium-phosphate, Magnetron sputter deposition, Polylactic acid",
author = "Tverdokhlebov, {S. I.} and Bolbasov, {E. N.} and Shesterikov, {E. V.} and Antonova, {L. V.} and Golovkin, {A. S.} and Matveeva, {V. G.} and Petlin, {Danila Gennadievich} and Anissimov, {Y. G.}",
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TY - JOUR

T1 - Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility

AU - Tverdokhlebov, S. I.

AU - Bolbasov, E. N.

AU - Shesterikov, E. V.

AU - Antonova, L. V.

AU - Golovkin, A. S.

AU - Matveeva, V. G.

AU - Petlin, Danila Gennadievich

AU - Anissimov, Y. G.

PY - 2015/2/28

Y1 - 2015/2/28

N2 - Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.

AB - Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.

KW - Biocompatibility

KW - Biomaterial

KW - Calcium-phosphate

KW - Magnetron sputter deposition

KW - Polylactic acid

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JF - Applied Surface Science

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