Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility

S. I. Tverdokhlebov, E. N. Bolbasov, E. V. Shesterikov, L. V. Antonova, A. S. Golovkin, V. G. Matveeva, Danila Gennadievich Petlin, Y. G. Anissimov

The Weinberg Research Center

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.

Original language	English
Pages (from-to)	32-39
Number of pages	8
Journal	Applied Surface Science
Volume	329
DOIs	https://doi.org/10.1016/j.apsusc.2014.12.127
Publication status	Published - 28 Feb 2015

Fingerprint

Sputter deposition

Durapatite

Biocompatibility

Hydroxyapatite

Plasmas

Acids

Surface morphology

Surface treatment

Crystallization

X ray spectroscopy

Phosphorus

Sputtering

Toxicity

Infrared spectroscopy

Calcium

Atomic force microscopy

Bone

poly(lactic acid)

Ions

Oxygen

Keywords

Biocompatibility
Biomaterial
Calcium-phosphate
Magnetron sputter deposition
Polylactic acid

ASJC Scopus subject areas

Surfaces, Coatings and Films

Cite this

Tverdokhlebov, S. I., Bolbasov, E. N., Shesterikov, E. V., Antonova, L. V., Golovkin, A. S., Matveeva, V. G., ... Anissimov, Y. G. (2015). Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility. Applied Surface Science, 329, 32-39. https://doi.org/10.1016/j.apsusc.2014.12.127

Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility. / Tverdokhlebov, S. I.; Bolbasov, E. N.; Shesterikov, E. V.; Antonova, L. V.; Golovkin, A. S.; Matveeva, V. G.; Petlin, Danila Gennadievich; Anissimov, Y. G.

In: Applied Surface Science, Vol. 329, 28.02.2015, p. 32-39.

Research output: Contribution to journal › Article

Tverdokhlebov, SI , Bolbasov, EN , Shesterikov, EV, Antonova, LV, Golovkin, AS, Matveeva, VG, Petlin, DG & Anissimov, YG 2015, 'Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility', Applied Surface Science, vol. 329, pp. 32-39. https://doi.org/10.1016/j.apsusc.2014.12.127

Tverdokhlebov SI , Bolbasov EN , Shesterikov EV, Antonova LV, Golovkin AS, Matveeva VG et al. Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility. Applied Surface Science. 2015 Feb 28;329:32-39. https://doi.org/10.1016/j.apsusc.2014.12.127

Tverdokhlebov, S. I. ; Bolbasov, E. N. ; Shesterikov, E. V. ; Antonova, L. V. ; Golovkin, A. S. ; Matveeva, V. G. ; Petlin, Danila Gennadievich ; Anissimov, Y. G. / Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility. In: Applied Surface Science. 2015 ; Vol. 329. pp. 32-39.

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AB - Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.

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Access to Document

10.1016/j.apsusc.2014.12.127