TY - JOUR
T1 - Modification of PCL Scaffolds by Reactive Magnetron Sputtering
T2 - A Possibility for Modulating Macrophage Responses
AU - Stankevich, Ksenia S.
AU - Kudryavtseva, Valeriya L.
AU - Bolbasov, Evgeny N.
AU - Shesterikov, Evgeny V.
AU - Larionova, Irina V.
AU - Shapovalova, Yelena G.
AU - Domracheva, Liubov V.
AU - Volokhova, Apollinariya A.
AU - Kurzina, Irina A.
AU - Zhukov, Yuri M.
AU - Malashicheva, Anna B.
AU - Kzhyshkowska, Julia G.
AU - Tverdokhlebov, Sergei I.
PY - 2020/7/13
Y1 - 2020/7/13
N2 - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.
AB - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.
KW - DFT
KW - immune response
KW - macrophage
KW - magnetron sputtering
KW - poly(ϵ-caprolactone) scaffolds
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U2 - 10.1021/acsbiomaterials.0c00440
DO - 10.1021/acsbiomaterials.0c00440
M3 - Article
AN - SCOPUS:85090347854
VL - 6
SP - 3967
EP - 3974
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
SN - 2373-9878
IS - 7
ER -