Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses

Abstract

Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.

Original language	English
Pages (from-to)	3967-3974
Number of pages	8
Journal	ACS Biomaterials Science and Engineering
Volume	6
Issue number	7
DOIs	https://doi.org/10.1021/acsbiomaterials.0c00440
Publication status	Published - 13 Jul 2020

Keywords

DFT
immune response
macrophage
magnetron sputtering
poly(ϵ-caprolactone) scaffolds

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

Access to Document

10.1021/acsbiomaterials.0c00440

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Stankevich, K. S., Kudryavtseva, V. L., Bolbasov, E. N., Shesterikov, E. V., Larionova, I. V., Shapovalova, Y. G., Domracheva, L. V., Volokhova, A. A., Kurzina, I. A., Zhukov, Y. M., Malashicheva, A. B., Kzhyshkowska, J. G., & Tverdokhlebov, S. I. (2020). Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses. ACS Biomaterials Science and Engineering, 6(7), 3967-3974. https://doi.org/10.1021/acsbiomaterials.0c00440

Modification of PCL Scaffolds by Reactive Magnetron Sputtering : A Possibility for Modulating Macrophage Responses. / Stankevich, Ksenia S.; Kudryavtseva, Valeriya L.; Bolbasov, Evgeny N.; Shesterikov, Evgeny V.; Larionova, Irina V.; Shapovalova, Yelena G.; Domracheva, Liubov V.; Volokhova, Apollinariya A.; Kurzina, Irina A.; Zhukov, Yuri M.; Malashicheva, Anna B.; Kzhyshkowska, Julia G.; Tverdokhlebov, Sergei I.

In: ACS Biomaterials Science and Engineering, Vol. 6, No. 7, 13.07.2020, p. 3967-3974.

Research output: Contribution to journal › Article › peer-review

Stankevich, KS , Kudryavtseva, VL , Bolbasov, EN , Shesterikov, EV, Larionova, IV, Shapovalova, YG, Domracheva, LV, Volokhova, AA, Kurzina, IA, Zhukov, YM, Malashicheva, AB, Kzhyshkowska, JG & Tverdokhlebov, SI 2020, 'Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses', ACS Biomaterials Science and Engineering, vol. 6, no. 7, pp. 3967-3974. https://doi.org/10.1021/acsbiomaterials.0c00440

Stankevich, Ksenia S. ; Kudryavtseva, Valeriya L. ; Bolbasov, Evgeny N. ; Shesterikov, Evgeny V. ; Larionova, Irina V. ; Shapovalova, Yelena G. ; Domracheva, Liubov V. ; Volokhova, Apollinariya A. ; Kurzina, Irina A. ; Zhukov, Yuri M. ; Malashicheva, Anna B. ; Kzhyshkowska, Julia G. ; Tverdokhlebov, Sergei I. / Modification of PCL Scaffolds by Reactive Magnetron Sputtering : A Possibility for Modulating Macrophage Responses. In: ACS Biomaterials Science and Engineering. 2020 ; Vol. 6, No. 7. pp. 3967-3974.

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abstract = "Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity. ",

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AU - Bolbasov, Evgeny N.

AU - Shesterikov, Evgeny V.

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AU - Shapovalova, Yelena G.

AU - Domracheva, Liubov V.

AU - Volokhova, Apollinariya A.

AU - Kurzina, Irina A.

AU - Zhukov, Yuri M.

AU - Malashicheva, Anna B.

AU - Kzhyshkowska, Julia G.

AU - Tverdokhlebov, Sergei I.

PY - 2020/7/13

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N2 - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.

AB - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.

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