Modeling of electroporation induced by pulsed electric fields in irregularly shaped cells

Luciano Mescia, Michele A. Chiapperino, Pietro Bia, Johan Gielis, Diego Caratelli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clarified, many research activities are focused on the development of suitable theoretical and numerical models. To this end, a nonlinear, nonlocal, dispersive, and space-time numerical algorithm has been developed and adopted to evaluate the transmembrane voltage and pore density along the perimeter of realistic irregularly shaped cells. The presented model is based on the Maxwell's equations and the asymptotic Smoluchowski's equation describing the pore dynamics. The dielectric dispersion of the media forming the cell has been modeled by using a general multirelaxation Debye-based formulation. The irregular shape of the cell is described by using the Gielis' superformula. Different test cases pertaining to red blood cells, muscular cells, cell in mitosis phase, and cancer-like cell have been investigated. For each type of cell, the influence of the relevant shape, the dielectric properties, and the external electric pulse characteristics on the electroporation process has been analyzed. The numerical results demonstrate that the proposed model is an efficient numerical tool to study the electroporation problem in arbitrary-shaped cells.

Original languageEnglish
Article number8106660
Pages (from-to)414-423
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume65
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Electric fields
Maxwell equations
Cell membranes
Dielectric properties
Numerical models
Blood
Permittivity
Cells
Electric potential

Keywords

  • biological cells
  • cell membrane potential
  • computational model
  • Pulsed electric field

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Modeling of electroporation induced by pulsed electric fields in irregularly shaped cells. / Mescia, Luciano; Chiapperino, Michele A.; Bia, Pietro; Gielis, Johan; Caratelli, Diego.

In: IEEE Transactions on Biomedical Engineering, Vol. 65, No. 2, 8106660, 01.02.2018, p. 414-423.

Research output: Contribution to journalArticle

Mescia, Luciano ; Chiapperino, Michele A. ; Bia, Pietro ; Gielis, Johan ; Caratelli, Diego. / Modeling of electroporation induced by pulsed electric fields in irregularly shaped cells. In: IEEE Transactions on Biomedical Engineering. 2018 ; Vol. 65, No. 2. pp. 414-423.
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