Abstract
Analysis of samples available in small volumes is an important challenge in analytical chemistry. Therefore, we have dealt with the development of a new miniaturized micro-volume voltammetric cell (MVVC) for the determination of reducible organic compounds in micro-volumes (20–50 μL). The MVVC is composed of two compartments, a micro-volume compartment, where the analyte is present along with the working electrode, separated by means of an agar membrane (about 2 mm) from a large-volume compartment containing the supporting electrolyte and the counter and reference electrodes. This MVVC was tested by the determination of sodium anthraquione-2-sulfonate as a model substance for structurally similar anthraquinone-based anti-cancer drugs. Using differential pulse voltammetry at a polished silver solid amalgam electrode, the following analytical parameters were obtained: linear dynamic range from 1 μmol L− 1 to 1 mmol L− 1, repeatability of 0.7% (on the concentration level 0.1 mmol L− 1), and limit of detection of 0.15 μmol L− 1.
| Original language | English |
|---|---|
| Pages (from-to) | 47-52 |
| Number of pages | 6 |
| Journal | Journal of Electroanalytical Chemistry |
| Volume | 821 |
| DOIs | |
| Publication status | Published - 15 Jul 2018 |
| Externally published | Yes |
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Keywords
- Anticancer drugs
- Solid amalgam electrode
- Urine analysis
- Voltammetry
- Water analysis
ASJC Scopus subject areas
- Analytical Chemistry
- Chemical Engineering(all)
- Electrochemistry
Cite this
Miniaturized voltammetric cell for cathodic voltammetry making use of an agar membrane. / Skalová, Štěpánka; Gonçalves, Luís Moreira; Navrátil, Tomáš; Barek, Jiří; Rodrigues, José António; Vyskočil, Vlastimil.
In: Journal of Electroanalytical Chemistry, Vol. 821, 15.07.2018, p. 47-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Miniaturized voltammetric cell for cathodic voltammetry making use of an agar membrane
AU - Skalová, Štěpánka
AU - Gonçalves, Luís Moreira
AU - Navrátil, Tomáš
AU - Barek, Jiří
AU - Rodrigues, José António
AU - Vyskočil, Vlastimil
PY - 2018/7/15
Y1 - 2018/7/15
N2 - Analysis of samples available in small volumes is an important challenge in analytical chemistry. Therefore, we have dealt with the development of a new miniaturized micro-volume voltammetric cell (MVVC) for the determination of reducible organic compounds in micro-volumes (20–50 μL). The MVVC is composed of two compartments, a micro-volume compartment, where the analyte is present along with the working electrode, separated by means of an agar membrane (about 2 mm) from a large-volume compartment containing the supporting electrolyte and the counter and reference electrodes. This MVVC was tested by the determination of sodium anthraquione-2-sulfonate as a model substance for structurally similar anthraquinone-based anti-cancer drugs. Using differential pulse voltammetry at a polished silver solid amalgam electrode, the following analytical parameters were obtained: linear dynamic range from 1 μmol L− 1 to 1 mmol L− 1, repeatability of 0.7% (on the concentration level 0.1 mmol L− 1), and limit of detection of 0.15 μmol L− 1.
AB - Analysis of samples available in small volumes is an important challenge in analytical chemistry. Therefore, we have dealt with the development of a new miniaturized micro-volume voltammetric cell (MVVC) for the determination of reducible organic compounds in micro-volumes (20–50 μL). The MVVC is composed of two compartments, a micro-volume compartment, where the analyte is present along with the working electrode, separated by means of an agar membrane (about 2 mm) from a large-volume compartment containing the supporting electrolyte and the counter and reference electrodes. This MVVC was tested by the determination of sodium anthraquione-2-sulfonate as a model substance for structurally similar anthraquinone-based anti-cancer drugs. Using differential pulse voltammetry at a polished silver solid amalgam electrode, the following analytical parameters were obtained: linear dynamic range from 1 μmol L− 1 to 1 mmol L− 1, repeatability of 0.7% (on the concentration level 0.1 mmol L− 1), and limit of detection of 0.15 μmol L− 1.
KW - Anticancer drugs
KW - Solid amalgam electrode
KW - Urine analysis
KW - Voltammetry
KW - Water analysis
UR - http://www.scopus.com/inward/record.url?scp=85039983983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039983983&partnerID=8YFLogxK
U2 - 10.1016/j.jelechem.2017.12.073
DO - 10.1016/j.jelechem.2017.12.073
M3 - Article
AN - SCOPUS:85039983983
VL - 821
SP - 47
EP - 52
JO - Journal of Electroanalytical Chemistry
JF - Journal of Electroanalytical Chemistry
SN - 0022-0728
ER -