Miniaturized voltammetric cell for cathodic voltammetry making use of an agar membrane

Štěpánka Skalová, Luís Moreira Gonçalves, Tomáš Navrátil, Jiří Barek, José António Rodrigues, Vlastimil Vyskočil

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Analysis of samples available in small volumes is an important challenge in analytical chemistry. Therefore, we have dealt with the development of a new miniaturized micro-volume voltammetric cell (MVVC) for the determination of reducible organic compounds in micro-volumes (20–50 μL). The MVVC is composed of two compartments, a micro-volume compartment, where the analyte is present along with the working electrode, separated by means of an agar membrane (about 2 mm) from a large-volume compartment containing the supporting electrolyte and the counter and reference electrodes. This MVVC was tested by the determination of sodium anthraquione-2-sulfonate as a model substance for structurally similar anthraquinone-based anti-cancer drugs. Using differential pulse voltammetry at a polished silver solid amalgam electrode, the following analytical parameters were obtained: linear dynamic range from 1 μmol L− 1 to 1 mmol L− 1, repeatability of 0.7% (on the concentration level 0.1 mmol L− 1), and limit of detection of 0.15 μmol L− 1.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJournal of Electroanalytical Chemistry
Volume821
DOIs
Publication statusPublished - 15 Jul 2018
Externally publishedYes

Fingerprint

Voltammetry
Agar
Membranes
Electrodes
Mercury amalgams
Anthraquinones
Silver
Organic compounds
Electrolytes
Sodium
Chemical analysis
Pharmaceutical Preparations

Keywords

  • Anticancer drugs
  • Solid amalgam electrode
  • Urine analysis
  • Voltammetry
  • Water analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Electrochemistry

Cite this

Miniaturized voltammetric cell for cathodic voltammetry making use of an agar membrane. / Skalová, Štěpánka; Gonçalves, Luís Moreira; Navrátil, Tomáš; Barek, Jiří; Rodrigues, José António; Vyskočil, Vlastimil.

In: Journal of Electroanalytical Chemistry, Vol. 821, 15.07.2018, p. 47-52.

Research output: Contribution to journalArticle

Skalová, Štěpánka ; Gonçalves, Luís Moreira ; Navrátil, Tomáš ; Barek, Jiří ; Rodrigues, José António ; Vyskočil, Vlastimil. / Miniaturized voltammetric cell for cathodic voltammetry making use of an agar membrane. In: Journal of Electroanalytical Chemistry. 2018 ; Vol. 821. pp. 47-52.
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