MIMICKING ISCHEMIC PRECONDITIONING PHENOMENON THROUGH THE IMPACT ON THE CANNABINOID RECEPTORS

ROLE OF PROTEIN KINASE AND NO-SYNTHASE

Yu B. Lishmanov, L. N. Maslov, A. V. Krylatov, I. G. Khaliulin

Research output: Contribution to journalArticle

Abstract

It was established that CB 1-receptors stimulation mimic preconditioning phenomena. Since the cardioprotective effect of cannabinoid HU-210 is occurred both in the experiments in vivo and in the experiments in vitro there are reasons to believe that the protective effect of HU-210 is me- diated via an activation of cardiac CB1-receptors. It is established that the cardioprotective effect of cannabinoid HU-2 10 is depends upon a stimulation ofprotein kinase C whereas NO-synthase is not involved in protective impact of CB1-receptor stimulation.

Original languageEnglish
Pages (from-to)909-920
Number of pages12
JournalRossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk
Volume101
Issue number8
Publication statusPublished - 1 Aug 2015

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Cannabinoid Receptor CB1
Cannabinoid Receptors
Ischemic Preconditioning
Cannabinoids
Nitric Oxide Synthase
Protein Kinases
Phosphotransferases
HU 211
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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