Method of evaluation of process of red blood cell sedimentation based on photometry of droplet samples

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Abstract

The paper focuses on research aimed at creating and testing a new approach to evaluate the processes of aggregation and sedimentation of red blood cells for purpose of its use in clinical laboratory diagnostics. The proposed method is based on photometric analysis of blood sample formed as a sessile drop. The results of clinical approbation of this method are given in the paper. Analysis of the processes occurring in the sample in the form of sessile drop during the process of blood cells sedimentation is described. The results of experimental studies to evaluate the effect of the droplet sample focusing properties on light radiation transmittance are presented. It is shown that this method significantly reduces the sample volume and provides sufficiently high sensitivity to the studied processes.

Original language	English
Pages (from-to)	621-630
Number of pages	10
Journal	Medical and Biological Engineering and Computing
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s11517-016-1542-5
Publication status	Published - 1 Apr 2017

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Keywords

Aggregation
Blood
Erythrocyte sedimentation rate
Photometry

ASJC Scopus subject areas

Biomedical Engineering
Computer Science Applications

Cite this

Aristov, A., & Nosova, E. (2017). Method of evaluation of process of red blood cell sedimentation based on photometry of droplet samples. Medical and Biological Engineering and Computing, 55(4), 621-630. https://doi.org/10.1007/s11517-016-1542-5

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10.1007/s11517-016-1542-5