Abstract
We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with 99mTc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity–time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.
| Original language | English |
|---|---|
| Pages (from-to) | 864-866 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 160 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Apr 2016 |
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Keywords
- coronary heart disease
- myocardial reserve
- positron emission tomography
- single-photon emission computed tomography
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Method for Studying the Myocardial Blood Flow Reserve by Load Dynamic Single-Photon Emission Computed Tomography. / Mochula, A. V.; Zavadovsky, K. V.; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 160, No. 6, 01.04.2016, p. 864-866.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Method for Studying the Myocardial Blood Flow Reserve by Load Dynamic Single-Photon Emission Computed Tomography
AU - Mochula, A. V.
AU - Zavadovsky, K. V.
AU - Lishmanov, Yu B.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with 99mTc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity–time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.
AB - We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with 99mTc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity–time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.
KW - coronary heart disease
KW - myocardial reserve
KW - positron emission tomography
KW - single-photon emission computed tomography
UR - http://www.scopus.com/inward/record.url?scp=84966546644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84966546644&partnerID=8YFLogxK
U2 - 10.1007/s10517-016-3328-z
DO - 10.1007/s10517-016-3328-z
M3 - Article
C2 - 27165060
AN - SCOPUS:84966546644
VL - 160
SP - 864
EP - 866
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 6
ER -