Method for Studying the Myocardial Blood Flow Reserve by Load Dynamic Single-Photon Emission Computed Tomography

A. V. Mochula, K. V. Zavadovsky, Yu B. Lishmanov

Research output: Contribution to journalArticle

3 Citations (Scopus)


We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with 99mTc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity–time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.

Original languageEnglish
Pages (from-to)864-866
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number6
Publication statusPublished - 1 Apr 2016



  • coronary heart disease
  • myocardial reserve
  • positron emission tomography
  • single-photon emission computed tomography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this