TY - JOUR
T1 - Metabolic single-photon emission computed tomography with the new radiopharmaceutical 99mtc-1-thio-d-glucose in the diagnosis and monitoring of the primary breast lymphoma (Case report)
AU - Dudnikova, Ekaterina A.
AU - Chernov, Vladimir I.
AU - Muravleva, Albina V.
AU - Kravchuk, Tatyana L.
AU - Zelchan, Roman V.
AU - Medvedeva, Аnna A.
AU - Bragina, Olga D.
AU - Simolina, Elena I.
AU - Popova, Nataliya O.
AU - Vysockaja, Vitalina V.
AU - Lukina, Natalia M.
AU - Shatalova, Vasilisa A.
AU - Shpileva, Olga V.
AU - Goldberg, Alexey V.
AU - Goldberg, Viktor E.
N1 - Funding Information:
This work was financially supported by Project 075-15-2019-1925 Decree of the Government of the Russian Federation 220.2019, funded by the Ministry of Science and Higher Education of the Russian Federation. Conflict of interest The authors declare that they have no conflict of interest.
Publisher Copyright:
© 2020, Tomsk National Research Medical Center of the Russian Academy of Sciences. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - The article shows the feasibility of detecting and monitoring primary breast diffuse large B-cell lymphoma using single-photon emission computed tomography (SPECT) with 99mTc-1-thio-D-glucose (99mТс-TG), a new radiopharmaceutical. The innovative radiopharmaceutical makes it possible to evaluate the metabolism of tumor tissue without using positron emission tomography. The findings of99mTc-TG SPECT obtained during diagnosis and monitoring of the patient were confirmed by the results of computed tomography. A comprehensive examination of the patient, including 99mTc-TG SPECT, made it possible to diagnose a rare case of primary breast lymphoma. Primary breast lymphoma accounts for 1.7-2.2 % of all extranodal non- Hodgkin lymphomas. Diffuse large B-cell lymphoma is the most common histological type occurring usually as a unilateral palpable tumor in middle-aged women. Extranodal lymphomas account for less than 0.5 % of all malignant neoplasms of the breast. After 6 courses of immunochemotherapy, the patient underwent 99mTc-TG SPECT, which demonstrated persistent hypermetabolic activity in the breast. The patient received radiation therapy to the remaining tumor of the left breast. The patient is in remission and followed up at the Cancer Research Institute of Tomsk National Research Medical Center. Thus, 99mTc-TG SPECT is believed to be a promising method for visualizing primary breast lymphomas and assessing their treatment outcomes. It is an alternative to the standard approach using 18F-FDG positron emission tomography. The method compares favorably with positron emission tomography with its wide availability and low cost of study.
AB - The article shows the feasibility of detecting and monitoring primary breast diffuse large B-cell lymphoma using single-photon emission computed tomography (SPECT) with 99mTc-1-thio-D-glucose (99mТс-TG), a new radiopharmaceutical. The innovative radiopharmaceutical makes it possible to evaluate the metabolism of tumor tissue without using positron emission tomography. The findings of99mTc-TG SPECT obtained during diagnosis and monitoring of the patient were confirmed by the results of computed tomography. A comprehensive examination of the patient, including 99mTc-TG SPECT, made it possible to diagnose a rare case of primary breast lymphoma. Primary breast lymphoma accounts for 1.7-2.2 % of all extranodal non- Hodgkin lymphomas. Diffuse large B-cell lymphoma is the most common histological type occurring usually as a unilateral palpable tumor in middle-aged women. Extranodal lymphomas account for less than 0.5 % of all malignant neoplasms of the breast. After 6 courses of immunochemotherapy, the patient underwent 99mTc-TG SPECT, which demonstrated persistent hypermetabolic activity in the breast. The patient received radiation therapy to the remaining tumor of the left breast. The patient is in remission and followed up at the Cancer Research Institute of Tomsk National Research Medical Center. Thus, 99mTc-TG SPECT is believed to be a promising method for visualizing primary breast lymphomas and assessing their treatment outcomes. It is an alternative to the standard approach using 18F-FDG positron emission tomography. The method compares favorably with positron emission tomography with its wide availability and low cost of study.
KW - Tc-1-thio-D-glucose
KW - Positron emission tomography
KW - Primary breast lymphoma
KW - Radiopharmaceutical
KW - Single-photon emission computed tomography
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U2 - 10.21294/1814-4861-2020-19-5-145-153
DO - 10.21294/1814-4861-2020-19-5-145-153
M3 - Article
AN - SCOPUS:85096224239
VL - 19
SP - 145
EP - 153
JO - Siberian Journal of Oncology
JF - Siberian Journal of Oncology
SN - 1814-4861
IS - 5
ER -