Issledovanie mekhanizmov NO-zavisimogo rasslableniia gladkikh myshts aorty krysy s pomoshch'iu nitrosoedinenii.

Translated title of the contribution: Mechanisms of NO-dependent relaxation in smooth muscles of the rat aorta with nitro compounds

I. V. Kovalev, A. G. Popov, A. A. Panov, I. L. Borodin, I. D. Afinogenova, L. V. Kapilevich, M. B. Baskakov, M. A. Medvedev

Research output: Contribution to journalArticle

Abstract

The membrane potential and smooth muscle tension in rat aorta were studied by the method of sucrose gap junction. It was found that sodium nitroprusside and nitroglycerin produced a dose-dependent membrane repolarization and smooth muscle cell relaxation in rat aorta preliminarily contracted and depolarized by hyperpotassium (40 mM) or phenylephrine solutions. The relaxation effect of sodium nitroprusside was more pronounced on the phenylephrine background. The effect of nitroglycerin showed a different kinetics in time and led to the tolerance development. The effects of both nitro compounds were inhibited by pretreatment with Methylene Blue or potassium channel blockers. It is suggested that nitro vasodilators are involved in the NO-dependent processes in smooth muscle cells of aorta through cGMP-mediated activation of the potassium conductivity and by changing the efficiency of operation of the protein kinase C branch of the Ca2+ signal system.

Original languageRussian
Pages (from-to)33-36
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume64
Issue number3
Publication statusPublished - May 2001
Externally publishedYes

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Nitro Compounds
Smooth Muscle
Muscle
Aorta
Rats
Nitroglycerin
Nitroprusside
Phenylephrine
Smooth Muscle Myocytes
Cells
Potassium Channel Blockers
Membranes
Muscle Tonus
Signal systems
Muscle Relaxation
Methylene Blue
Gap Junctions
Vasodilator Agents
Membrane Potentials
Protein Kinase C

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kovalev, I. V., Popov, A. G., Panov, A. A., Borodin, I. L., Afinogenova, I. D., Kapilevich, L. V., ... Medvedev, M. A. (2001). Issledovanie mekhanizmov NO-zavisimogo rasslableniia gladkikh myshts aorty krysy s pomoshch'iu nitrosoedinenii. Eksperimental'naya i Klinicheskaya Farmakologiya, 64(3), 33-36.

Issledovanie mekhanizmov NO-zavisimogo rasslableniia gladkikh myshts aorty krysy s pomoshch'iu nitrosoedinenii. / Kovalev, I. V.; Popov, A. G.; Panov, A. A.; Borodin, I. L.; Afinogenova, I. D.; Kapilevich, L. V.; Baskakov, M. B.; Medvedev, M. A.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 64, No. 3, 05.2001, p. 33-36.

Research output: Contribution to journalArticle

Kovalev, IV, Popov, AG, Panov, AA, Borodin, IL, Afinogenova, ID, Kapilevich, LV, Baskakov, MB & Medvedev, MA 2001, 'Issledovanie mekhanizmov NO-zavisimogo rasslableniia gladkikh myshts aorty krysy s pomoshch'iu nitrosoedinenii.', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 64, no. 3, pp. 33-36.
Kovalev, I. V. ; Popov, A. G. ; Panov, A. A. ; Borodin, I. L. ; Afinogenova, I. D. ; Kapilevich, L. V. ; Baskakov, M. B. ; Medvedev, M. A. / Issledovanie mekhanizmov NO-zavisimogo rasslableniia gladkikh myshts aorty krysy s pomoshch'iu nitrosoedinenii. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2001 ; Vol. 64, No. 3. pp. 33-36.
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