Mechanism of the ligand-free CuI-catalyzed azide-alkyne cycloaddition reaction

Valentin O. Rodionov, Valery V. Fokin, M. G. Finn

Research output: Contribution to journalArticlepeer-review

488 Citations (Scopus)


(Chemical Equation Presented) A powerful engine: The Cu-catalyzed azide-alkyne cycloaddition depends on rapid formation of CuI- acetylide complexes from terminal alkynes 2 and their ability to activate organic azides 1. A kinetics study uncovered a bimolecular dependence on the metal and an unusually fast intramolecular variant of the process. The results suggest the importance of 3 as a reactive intermediate.

Original languageEnglish
Pages (from-to)2210-2215
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number15
Publication statusPublished - 8 Apr 2005
Externally publishedYes


  • Alkynes
  • Azides
  • Click chemistry
  • Copper
  • Cycloaddition

ASJC Scopus subject areas

  • Chemistry(all)

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