Mechanical, in vitro corrosion resistance and biological compatibility of cast and annealed Ti25Nb10Zr alloy

Cosmin M. Cotrut, Anca C. Parau, Ana I. Gherghilescu, Irina Titorencu, Iulian Pana, Danut V. Cojocaru, Vasile Pruna, Lidia Constantin, Ioan Dan, Diana M. Vranceanu, Alina Vladescu

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Compared to other alloys, Ti6Al4V is the most used in medicine. In recent years, concerns regarding the toxicity of Al and V elements found in the composition of Ti6Al4V have drawn the attention of the scientific community, due to the release of Al or V ions after long term exposure to human body fluids which can lead to a negative response of the human host. Based on this, the aim of the paper was to manufacture a Ti25Nb10Zr alloy consisting of biocompatible elements which can replace Ti6Al4V usage in medical applications. In order to prove that this alloy possessed improved properties, the mechanical, wear and corrosion resistance, wettability, and cell viability were performed in comparison with those of the Ti6Al4V alloy. The corrosion behavior of this new alloy in simulated body fluid (SBF) and Hank solutions is superior to that of Ti6Al4V. The cast Ti25Nb10Zr alloy has a good tribological performance in SBF, while annealed Ti25Nb10Zr alloy is better in Hank solution. Cell viability and proliferation assay after five days indicated that Ti25Nb10Zr presented a good viability and proliferation with values of approximately 7% and 10% higher, respectively, than the ones registered for pure Ti. When compared with Ti6Al4V, the obtained results for Ti25Nb10Zr indicated smaller values with 20% in the case of both tests. Overall, it can be concluded that cell proliferation and viability tests indicated that the biocompatibility of the Ti25Nb10Zr alloy is as good as pure Ti and Ti6Al4V alloy.

Original languageEnglish
Article number86
Issue number3
Publication statusPublished - 8 Mar 2017


  • Cell viability
  • Corrosion resistance
  • Ti6Al4V and Ti25Nb10Zr alloys
  • Wear and friction

ASJC Scopus subject areas

  • Materials Science(all)

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