Measurement of Whole Blood Coagulation Time by Laser Speckle Pattern Correlation

Abstract

We present here the results obtained by correlation analysis of digital speckle patterns to assess coagulation time in citrated whole blood. The spread of coagulation time values in experiments was no more than 25% for an essentially healthy cohort of laboratory animals. Studies of normal and pathological plasma showed that the method is able to detect pathological hemostasis. The ability to create a new universal optical coagulometer analyzing citrated and native blood, as well as whole blood, is discussed. Estimation of citrated blood clotting time is an intermediate stage in developing a test for native blood.

Original language	English
Pages (from-to)	262-266
Number of pages	5
Journal	Biomedical Engineering
Volume	54
Issue number	4
DOIs	https://doi.org/10.1007/s10527-020-10018-2
Publication status	Published - Nov 2020

ASJC Scopus subject areas

Medicine (miscellaneous)
Biomedical Engineering
Medical Laboratory Technology

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title = "Measurement of Whole Blood Coagulation Time by Laser Speckle Pattern Correlation",

abstract = "We present here the results obtained by correlation analysis of digital speckle patterns to assess coagulation time in citrated whole blood. The spread of coagulation time values in experiments was no more than 25% for an essentially healthy cohort of laboratory animals. Studies of normal and pathological plasma showed that the method is able to detect pathological hemostasis. The ability to create a new universal optical coagulometer analyzing citrated and native blood, as well as whole blood, is discussed. Estimation of citrated blood clotting time is an intermediate stage in developing a test for native blood.",

author = "Liushnevskaya, {Yu D.} and Gubarev, {F. A.} and L. Li and Nosarev, {A. V.} and Gusakova, {V. S.}",

year = "2020",

month = nov,

doi = "10.1007/s10527-020-10018-2",

language = "English",

volume = "54",

pages = "262--266",

journal = "Bio-Medical Engineering",

issn = "0006-3398",

publisher = "Springer New York",

number = "4",

}

TY - JOUR

T1 - Measurement of Whole Blood Coagulation Time by Laser Speckle Pattern Correlation

AU - Liushnevskaya, Yu D.

AU - Gubarev, F. A.

AU - Li, L.

AU - Nosarev, A. V.

AU - Gusakova, V. S.

PY - 2020/11

Y1 - 2020/11

N2 - We present here the results obtained by correlation analysis of digital speckle patterns to assess coagulation time in citrated whole blood. The spread of coagulation time values in experiments was no more than 25% for an essentially healthy cohort of laboratory animals. Studies of normal and pathological plasma showed that the method is able to detect pathological hemostasis. The ability to create a new universal optical coagulometer analyzing citrated and native blood, as well as whole blood, is discussed. Estimation of citrated blood clotting time is an intermediate stage in developing a test for native blood.

AB - We present here the results obtained by correlation analysis of digital speckle patterns to assess coagulation time in citrated whole blood. The spread of coagulation time values in experiments was no more than 25% for an essentially healthy cohort of laboratory animals. Studies of normal and pathological plasma showed that the method is able to detect pathological hemostasis. The ability to create a new universal optical coagulometer analyzing citrated and native blood, as well as whole blood, is discussed. Estimation of citrated blood clotting time is an intermediate stage in developing a test for native blood.

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