Man-made antibodies and immunoconjugates with desired properties: Function optimization using structural engineering

S. M. Deyev, E. N. Lebedenko, L. E. Petrovskaya, D. A. Dolgikh, A. G. Gabibov, M. P. Kirpichnikov

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The review outlines progress and problems in the design of non-natural antibodies for clinical applications over the past 10 - 15 years. The modular structure of natural antibodies and approaches to its targeted modifications and combination with other structural elements and effector molecules are considered. The review covers modern methods for immunoglobulin engineering and promising strategies for the creation and applications of monoclonal antibodies, their derivatives and analogues, including abzymes and scaffolds, oriented to the use in the diagnosis and targeted therapy of cancer and other socially significant diseases. The bibliography includes 225 references.

Original languageEnglish
Pages (from-to)1-26
Number of pages26
JournalRussian Chemical Reviews
Volume84
Issue number1
DOIs
Publication statusPublished - 2015

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ASJC Scopus subject areas

  • Chemistry(all)

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