Magnetic silica hybrids modified with guanidine containing co-polymers for drug delivery applications

Alexander S. Timin, Svetlana Yu Khashirova, Evgeniy V. Rumyantsev, Alexander A. Goncharenko

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Guanidine containing co-polymers grafted onto silica nanoparticles to form core-shell structure were prepared by sol-gel method in the presence of γ-Fe2O3 nanoparticles. The morphological features for uncoated and coated silica particles have been characterized with scanning electron microscopy. The results show that the polymer coated silicas exhibit spherical morphology with rough polymeric surface covered by γ-Fe2O3 nanoparticles. The grafting amount of guanidine containing co-polymers evaluated by thermogravimetric analysis was in the range from 17 to 30%. Then, the drug loading properties and cumulative release of silica hybrids modified with guanidine containing co-polymers were evaluated using molsidomine as a model drug. It was shown that after polymer grafting the loading content of molsidomine could reach up to 3.42 ± 0.21 and 2.34 ± 0.14 mg/g respectively. The maximum drug release of molsidomine is achieved at pH 1.6 (approximately 71-75% release at 37 °C), whereas at pH 7.4 drug release is lower (50.4-59.6% release at 37 °C). These results have an important implication that our magneto-controlled silica hybrids modified with guanidine containing co-polymers are promising as drug carriers with controlled behaviour under influence of magnetic field.

Original languageEnglish
Pages (from-to)20-28
Number of pages9
JournalMaterials Science and Engineering C
Volume64
DOIs
Publication statusPublished - 1 Jul 2016

Fingerprint

guanidines
Guanidine
Drug delivery
Silicon Dioxide
delivery
Polymers
drugs
Molsidomine
Silica
silicon dioxide
polymers
Nanoparticles
Pharmaceutical Preparations
nanoparticles
Drug Carriers
Sol-gel process
Thermogravimetric analysis
gels
Magnetic fields
Scanning electron microscopy

Keywords

  • Core-shell structure
  • Drug carrier
  • Magnetic properties
  • Polymer grafting
  • Silica core

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Magnetic silica hybrids modified with guanidine containing co-polymers for drug delivery applications. / Timin, Alexander S.; Khashirova, Svetlana Yu; Rumyantsev, Evgeniy V.; Goncharenko, Alexander A.

In: Materials Science and Engineering C, Vol. 64, 01.07.2016, p. 20-28.

Research output: Contribution to journalArticle

Timin, Alexander S. ; Khashirova, Svetlana Yu ; Rumyantsev, Evgeniy V. ; Goncharenko, Alexander A. / Magnetic silica hybrids modified with guanidine containing co-polymers for drug delivery applications. In: Materials Science and Engineering C. 2016 ; Vol. 64. pp. 20-28.
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