Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P

W. Yu. Ussov, M. L. Belyanin, A. I. Bezlepkin, O. Yu. Borodin, E. E. Bobrikova, N. L. Shimanovskii

Research output: Contribution to journalArticle

Abstract

Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N’,N’-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.19±0.11 for the central areas and 1.47±0.17 for the peripheral ones. The pituitary (1.18±0.05) and vascular plexuses of the lateral ventricles (1.12±0.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.

Original languageEnglish
Pages (from-to)715-718
JournalBulletin of Experimental Biology and Medicine
Volume161
Issue number5
DOIs
Publication statusPublished - 2016

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Brain
Magnetic Resonance Imaging
Dogs
Magnetic resonance
Visualization
Babesia
Imaging techniques
Lateral Ventricles
Wounds and Injuries
Manganese
Brain Injuries
Contrast Media
Amplification
Blood Vessels
Injections
Acids
Infection
CDTA
1,2-cyclohexanediamine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P. / Ussov, W. Yu.; Belyanin, M. L.; Bezlepkin, A. I.; Borodin, O. Yu.; Bobrikova, E. E.; Shimanovskii, N. L.

In: Bulletin of Experimental Biology and Medicine, Vol. 161, No. 5, 2016, p. 715-718.

Research output: Contribution to journalArticle

Ussov, W. Yu. ; Belyanin, M. L. ; Bezlepkin, A. I. ; Borodin, O. Yu. ; Bobrikova, E. E. ; Shimanovskii, N. L. / Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P. In: Bulletin of Experimental Biology and Medicine. 2016 ; Vol. 161, No. 5. pp. 715-718.
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