Magnetic polymer-silica composites as bioluminescent sensors for bilirubin detection

Alexander S. Timin, Alexey V. Solomonov, Akiko Kumagai, Atsushi Miyawaki, Svetlana Yu Khashirova, Azamat Zhansitov, Evgeniy V. Rumyantsev

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The synthesis of multifunctional nano-sized materials is leading to the rapid development of key application, including improved drug delivery, bioimaging and protein separation. In this work, magnetic silica particles modified with novel guanidine containing co-polymers were manufactured via sol-gel method. To evaluate the chemical composition of our prepared samples, FT-IR spectroscopy and thermogravimetry were conducted. Scanning electron microscopy was used in order to investigate the morphology of final products after modification by guanidine containing co-polymers and iron nanoparticles. In addition, the surface of polymer-silica composites was functionalized by the novel bilirubin-inducible fluorescent protein UnaG. In an aqueous bilirubin solution, the silica particles decorated with the polymer-UnaG have showed bright fluorescence. Synthesis and characterization of these hybrid materials allow developing of new multifunctional nano-sized materials, which will be used for detection and separation of bilirubin, a lipophilic heme catabolite that is a clinical diagnostic for liver function.

Original languageEnglish
Pages (from-to)422-429
Number of pages8
JournalMaterials Chemistry and Physics
Volume183
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Bilirubin
  • Magnetic and fluorescent properties
  • Polyguanidine
  • Polymer functionalization
  • Silica core
  • UnaG protein

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

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    Timin, A. S., Solomonov, A. V., Kumagai, A., Miyawaki, A., Khashirova, S. Y., Zhansitov, A., & Rumyantsev, E. V. (2016). Magnetic polymer-silica composites as bioluminescent sensors for bilirubin detection. Materials Chemistry and Physics, 183, 422-429. https://doi.org/10.1016/j.matchemphys.2016.08.048