Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy

Maxim Nikitin, Raul Gabbasov, Valery Cherepanov, Mikhail Chuev, Mikhail Polikarpov, Vladislav Panchenko, Sergey Deyev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)

Abstract

Magnetic nanoparticles belong to the most promising nanosized objects for biomedical applications. However, little is known about clearance of magnetic nanoparticles from the organism. In this work superparamagnetic iron oxide particles fluidMAG-ARA were injected into tail vein of mice at a dose of 17 mg per 20 g body weight. At various time intervals after the injection the mice were sacrificed and their organs collected. A Mössbauer study allowed to detect magnetic particles in the liver and spleen and showed the degradation of the particles with incorporation of exogenous iron into paramagnetic ferritin-like iron species.

Original languageEnglish
Title of host publication8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
Pages401-407
Number of pages7
Volume1311
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers - Rostock, Germany
Duration: 25 May 201029 May 2010

Conference

Conference8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
CountryGermany
CityRostock
Period25.5.1029.5.10

Fingerprint

degradation
nanoparticles
mice
spectroscopy
iron
body weight
spleen
clearances
veins
organisms
iron oxides
liver
organs
injection
intervals
dosage

Keywords

  • biodegradation
  • biotransformation
  • Magnetic nanoparticles
  • Mössbauer spectroscopy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Nikitin, M., Gabbasov, R., Cherepanov, V., Chuev, M., Polikarpov, M., Panchenko, V., & Deyev, S. (2010). Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy. In 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers (Vol. 1311, pp. 401-407) https://doi.org/10.1063/1.3530046

Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy. / Nikitin, Maxim; Gabbasov, Raul; Cherepanov, Valery; Chuev, Mikhail; Polikarpov, Mikhail; Panchenko, Vladislav; Deyev, Sergey.

8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. Vol. 1311 2010. p. 401-407.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nikitin, M, Gabbasov, R, Cherepanov, V, Chuev, M, Polikarpov, M, Panchenko, V & Deyev, S 2010, Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy. in 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. vol. 1311, pp. 401-407, 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Rostock, Germany, 25.5.10. https://doi.org/10.1063/1.3530046
Nikitin M, Gabbasov R, Cherepanov V, Chuev M, Polikarpov M, Panchenko V et al. Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy. In 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. Vol. 1311. 2010. p. 401-407 https://doi.org/10.1063/1.3530046
Nikitin, Maxim ; Gabbasov, Raul ; Cherepanov, Valery ; Chuev, Mikhail ; Polikarpov, Mikhail ; Panchenko, Vladislav ; Deyev, Sergey. / Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy. 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. Vol. 1311 2010. pp. 401-407
@inproceedings{5e74a4d7592046d39f32b0631cb806e3,
title = "Magnetic nanoparticle degradation in vivo studied by M{\"o}ssbauer spectroscopy",
abstract = "Magnetic nanoparticles belong to the most promising nanosized objects for biomedical applications. However, little is known about clearance of magnetic nanoparticles from the organism. In this work superparamagnetic iron oxide particles fluidMAG-ARA were injected into tail vein of mice at a dose of 17 mg per 20 g body weight. At various time intervals after the injection the mice were sacrificed and their organs collected. A M{\"o}ssbauer study allowed to detect magnetic particles in the liver and spleen and showed the degradation of the particles with incorporation of exogenous iron into paramagnetic ferritin-like iron species.",
keywords = "biodegradation, biotransformation, Magnetic nanoparticles, M{\"o}ssbauer spectroscopy",
author = "Maxim Nikitin and Raul Gabbasov and Valery Cherepanov and Mikhail Chuev and Mikhail Polikarpov and Vladislav Panchenko and Sergey Deyev",
year = "2010",
doi = "10.1063/1.3530046",
language = "English",
isbn = "9780735408661",
volume = "1311",
pages = "401--407",
booktitle = "8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers",

}

TY - GEN

T1 - Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy

AU - Nikitin, Maxim

AU - Gabbasov, Raul

AU - Cherepanov, Valery

AU - Chuev, Mikhail

AU - Polikarpov, Mikhail

AU - Panchenko, Vladislav

AU - Deyev, Sergey

PY - 2010

Y1 - 2010

N2 - Magnetic nanoparticles belong to the most promising nanosized objects for biomedical applications. However, little is known about clearance of magnetic nanoparticles from the organism. In this work superparamagnetic iron oxide particles fluidMAG-ARA were injected into tail vein of mice at a dose of 17 mg per 20 g body weight. At various time intervals after the injection the mice were sacrificed and their organs collected. A Mössbauer study allowed to detect magnetic particles in the liver and spleen and showed the degradation of the particles with incorporation of exogenous iron into paramagnetic ferritin-like iron species.

AB - Magnetic nanoparticles belong to the most promising nanosized objects for biomedical applications. However, little is known about clearance of magnetic nanoparticles from the organism. In this work superparamagnetic iron oxide particles fluidMAG-ARA were injected into tail vein of mice at a dose of 17 mg per 20 g body weight. At various time intervals after the injection the mice were sacrificed and their organs collected. A Mössbauer study allowed to detect magnetic particles in the liver and spleen and showed the degradation of the particles with incorporation of exogenous iron into paramagnetic ferritin-like iron species.

KW - biodegradation

KW - biotransformation

KW - Magnetic nanoparticles

KW - Mössbauer spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=79251588041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251588041&partnerID=8YFLogxK

U2 - 10.1063/1.3530046

DO - 10.1063/1.3530046

M3 - Conference contribution

SN - 9780735408661

VL - 1311

SP - 401

EP - 407

BT - 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers

ER -