Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy

Maxim Nikitin, Raul Gabbasov, Valery Cherepanov, Mikhail Chuev, Mikhail Polikarpov, Vladislav Panchenko, Sergey Deyev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)

Abstract

Magnetic nanoparticles belong to the most promising nanosized objects for biomedical applications. However, little is known about clearance of magnetic nanoparticles from the organism. In this work superparamagnetic iron oxide particles fluidMAG-ARA were injected into tail vein of mice at a dose of 17 mg per 20 g body weight. At various time intervals after the injection the mice were sacrificed and their organs collected. A Mössbauer study allowed to detect magnetic particles in the liver and spleen and showed the degradation of the particles with incorporation of exogenous iron into paramagnetic ferritin-like iron species.

Original languageEnglish
Title of host publication8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
Pages401-407
Number of pages7
Volume1311
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers - Rostock, Germany
Duration: 25 May 201029 May 2010

Conference

Conference8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
CountryGermany
CityRostock
Period25.5.1029.5.10

    Fingerprint

Keywords

  • biodegradation
  • biotransformation
  • Magnetic nanoparticles
  • Mössbauer spectroscopy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Nikitin, M., Gabbasov, R., Cherepanov, V., Chuev, M., Polikarpov, M., Panchenko, V., & Deyev, S. (2010). Magnetic nanoparticle degradation in vivo studied by Mössbauer spectroscopy. In 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers (Vol. 1311, pp. 401-407) https://doi.org/10.1063/1.3530046