Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia

Nikolay G. Krivonogov, Nataliya Y. Efimova, Konstantin W. Zavadovsky, Yuri B. Lishmanov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ventilation/perfusion lung scintigraphy was performed in 39 patients with verified diagnosis of community-acquired pneumonia (CAP) and in 14 patients with peripheral lung cancer. Ventilation/perfusion ratio, apical-basal gradients of ventilation (U/L(V)) and lung perfusion (U/L(P)), and alveolar capillary permeability of radionuclide aerosol were determined based on scintigraphy data. The study demonstrated that main signs of CAP were increases in ventilation/perfusion ratio, perfusion and ventilation gradient on a side of the diseased lung, and two-side increase in alveolar capillary permeability rate for radionuclide aerosol. Unlike this, scintigraphic signs of peripheral lung cancer comprise an increase in ventilation/perfusion ratio over 1.0 on a side of the diseased lung with its simultaneous decrease on a contralateral side, normal values of perfusion and ventilation gradients of both lungs, and delayed alveolar capillary clearance in the diseased lung compared with the intact lung.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
PublisherAmerican Institute of Physics Inc.
Volume1760
ISBN (Electronic)9780735414181
DOIs
Publication statusPublished - 2 Aug 2016
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 - Tomsk, Russian Federation
Duration: 22 Mar 201625 Mar 2016

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016
CountryRussian Federation
CityTomsk
Period22.3.1625.3.16

Keywords

  • alveolar capillary permeability
  • communityacquired pneumonia
  • peripheral lung cancer
  • ventilation-perfusion lung scintigraphy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Krivonogov, N. G., Efimova, N. Y., Zavadovsky, K. W., & Lishmanov, Y. B. (2016). Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia. In Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 (Vol. 1760). [020037] American Institute of Physics Inc.. https://doi.org/10.1063/1.4960256