Luminescence monitoring of particle delivery into rat skin in vivo

E. K. Volkova, I. Y. Yanina, E. A. Genina, L. E. Dolotov, A. N. Bashkatov, V. D. Genin, J. G. Konyukhova, A. P. Popov, M. D. Kozintseva, E. Speranskaya, M. Lomova, G. S. Terentyuk, A. B. Bucharskaya, N. A. Navolokin, I. Y. Goryacheva, V. I. Kochubey, D. A. Gorin, V. V. Tuchin, G. B. Sukhorukov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Delivery of upconversion microparticles [Y2O3:Yb, Er] and quantum dots (CuInS2/ZnS coated with PEG-based amphiphilic polymer) into rat skin using the fractional laser microablation has been studied in vivo. Luminescence spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis were used for visualization of nanoparticles in microchannels. Results have shown that the upconversion microparticles are detected more efficiently in comparison with the quantum dots. The fluorescence intensity of the inserted upconversion microparticles is higher, when the Omnipaque™ was applied as a skin optical clearing agent. The fluorescent images of upconversion nanoparticle distribution indicate the advantage of particle delivery into skin by ultrasound.

Original languageEnglish
Title of host publicationClinical and Biomedical Spectroscopy and Imaging IV
PublisherSPIE
Volume9537
ISBN (Electronic)9781628417029
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventClinical and Biomedical Spectroscopy and Imaging IV - Munich, Germany
Duration: 22 Jun 201524 Jun 2015

Conference

ConferenceClinical and Biomedical Spectroscopy and Imaging IV
CountryGermany
CityMunich
Period22.6.1524.6.15

Fingerprint

microparticles
Luminescence
rats
Rats
Quantum Dots
delivery
Skin
luminescence
Nanoparticles
Semiconductor quantum dots
histochemical analysis
Monitoring
quantum dots
Iohexol
nanoparticles
clearing
Confocal microscopy
Optical tomography
Optical Coherence Tomography
microchannels

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Volkova, E. K., Yanina, I. Y., Genina, E. A., Dolotov, L. E., Bashkatov, A. N., Genin, V. D., ... Sukhorukov, G. B. (2015). Luminescence monitoring of particle delivery into rat skin in vivo. In Clinical and Biomedical Spectroscopy and Imaging IV (Vol. 9537). [95371P] SPIE. https://doi.org/10.1117/12.2183718

Luminescence monitoring of particle delivery into rat skin in vivo. / Volkova, E. K.; Yanina, I. Y.; Genina, E. A.; Dolotov, L. E.; Bashkatov, A. N.; Genin, V. D.; Konyukhova, J. G.; Popov, A. P.; Kozintseva, M. D.; Speranskaya, E.; Lomova, M.; Terentyuk, G. S.; Bucharskaya, A. B.; Navolokin, N. A.; Goryacheva, I. Y.; Kochubey, V. I.; Gorin, D. A.; Tuchin, V. V.; Sukhorukov, G. B.

Clinical and Biomedical Spectroscopy and Imaging IV. Vol. 9537 SPIE, 2015. 95371P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Volkova, EK, Yanina, IY, Genina, EA, Dolotov, LE, Bashkatov, AN, Genin, VD, Konyukhova, JG, Popov, AP, Kozintseva, MD, Speranskaya, E, Lomova, M, Terentyuk, GS, Bucharskaya, AB, Navolokin, NA, Goryacheva, IY, Kochubey, VI, Gorin, DA, Tuchin, VV & Sukhorukov, GB 2015, Luminescence monitoring of particle delivery into rat skin in vivo. in Clinical and Biomedical Spectroscopy and Imaging IV. vol. 9537, 95371P, SPIE, Clinical and Biomedical Spectroscopy and Imaging IV, Munich, Germany, 22.6.15. https://doi.org/10.1117/12.2183718
Volkova EK, Yanina IY, Genina EA, Dolotov LE, Bashkatov AN, Genin VD et al. Luminescence monitoring of particle delivery into rat skin in vivo. In Clinical and Biomedical Spectroscopy and Imaging IV. Vol. 9537. SPIE. 2015. 95371P https://doi.org/10.1117/12.2183718
Volkova, E. K. ; Yanina, I. Y. ; Genina, E. A. ; Dolotov, L. E. ; Bashkatov, A. N. ; Genin, V. D. ; Konyukhova, J. G. ; Popov, A. P. ; Kozintseva, M. D. ; Speranskaya, E. ; Lomova, M. ; Terentyuk, G. S. ; Bucharskaya, A. B. ; Navolokin, N. A. ; Goryacheva, I. Y. ; Kochubey, V. I. ; Gorin, D. A. ; Tuchin, V. V. ; Sukhorukov, G. B. / Luminescence monitoring of particle delivery into rat skin in vivo. Clinical and Biomedical Spectroscopy and Imaging IV. Vol. 9537 SPIE, 2015.
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abstract = "Delivery of upconversion microparticles [Y2O3:Yb, Er] and quantum dots (CuInS2/ZnS coated with PEG-based amphiphilic polymer) into rat skin using the fractional laser microablation has been studied in vivo. Luminescence spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis were used for visualization of nanoparticles in microchannels. Results have shown that the upconversion microparticles are detected more efficiently in comparison with the quantum dots. The fluorescence intensity of the inserted upconversion microparticles is higher, when the Omnipaque™ was applied as a skin optical clearing agent. The fluorescent images of upconversion nanoparticle distribution indicate the advantage of particle delivery into skin by ultrasound.",
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AU - Volkova, E. K.

AU - Yanina, I. Y.

AU - Genina, E. A.

AU - Dolotov, L. E.

AU - Bashkatov, A. N.

AU - Genin, V. D.

AU - Konyukhova, J. G.

AU - Popov, A. P.

AU - Kozintseva, M. D.

AU - Speranskaya, E.

AU - Lomova, M.

AU - Terentyuk, G. S.

AU - Bucharskaya, A. B.

AU - Navolokin, N. A.

AU - Goryacheva, I. Y.

AU - Kochubey, V. I.

AU - Gorin, D. A.

AU - Tuchin, V. V.

AU - Sukhorukov, G. B.

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