Long-acting isosorbide dinitrate and molsidomin in the treatment of effort angina in patients with arterial hypotension

E. M. Idrisova, E. A. Kladieva, N. V. Borovkova, E. V. Vorobyeva, V. I. Chernov, R. S. Karpov

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. To compare effectiveness and tolerance of isosorbide dinitrate (ID) and molsidomin in retard forms in patients with effort angina (EA) in combination with arterial hypotension (AH). Material and methods. A randomised blind cross-over trial with lead-in placebo period trial compared efficiency of retard ID and molsidomin in 65 EA patients with AH (group 1) and 40 normotensive patients with coronary heart disease (group 2). Results. Bicycle exercise has shown that retard ID and molsidomin retard were highly effective in group 1 (97% vs 92%0 and group 2 (100 and 95%, respectively). Molsidomin retard treatment improved myocardial perfusion and was effective for a year in both groups. Conclusion. Retard ID was highly effective in anginal patients with AH but its tolerance is also high. Molsidomin retard is proposed as alternative treatment in anginal patients with AH.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalTerapevticheskii Arkhiv
Volume74
Issue number6
Publication statusPublished - 2002

Keywords

  • Angina
  • Arterial hypotension
  • Isosorbide dinitrate retard
  • Molsidomine retard
  • Scintigraphy of the myocardium

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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