Liver uptake of radiolabeled targeting proteins and peptides: Considerations for targeting peptide conjugate design

Seyed Jalal Hosseinimehr, Vladimir Tolmachev, Anna Orlova

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

Radionuclide imaging of molecular targets for cancer therapy is likely to be a powerful tool for patient stratification and response monitoring, allowing more personalized cancer treatment. Radiolabeled proteins and peptides are a promising class of imaging probes for visualization of molecular targets in vivo. However, hepatic uptake and hepatobiliary excretion of radioactivity can decrease imaging contrast, reducing the detection sensitivity of hepatic and extrahepatic abdominal metastases, respectively. In this article, we review factors that influence the hepatic uptake of radioactivity (e.g. the chemical nature of radiocatabolites and physicochemical properties of targeting peptides and linkers) to provide input for the rational design of peptide-based imaging probes.

Original languageEnglish
Pages (from-to)1224-1232
Number of pages9
JournalDrug Discovery Today
Volume17
Issue number21-22
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Liver uptake of radiolabeled targeting proteins and peptides: Considerations for targeting peptide conjugate design'. Together they form a unique fingerprint.

Cite this