Liver, lung, kidney and spleen macrophages in rats after intravenous administration of the modified magnetite nanoparticles

I. V. Mil'to

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    1 Citation (Scopus)

    Abstract

    Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.

    Original languageEnglish
    Pages (from-to)40-45
    Number of pages6
    JournalMorfologii{combining double inverted breve}a (Saint Petersburg, Russia)
    Volume146
    Issue number5
    Publication statusPublished - 2014

    Fingerprint

    Magnetite Nanoparticles
    Ferrosoferric Oxide
    Intravenous Administration
    Spleen
    Macrophages
    Kidney
    Lung
    Liver
    Phagocytes
    Microspheres
    Intravenous Injections
    Suspensions
    Macrophage Activation
    Nanostructures

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

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