Abstract
Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.
| Original language | English |
|---|---|
| Pages (from-to) | 40-45 |
| Number of pages | 6 |
| Journal | Morfologii{combining double inverted breve}a (Saint Petersburg, Russia) |
| Volume | 146 |
| Issue number | 5 |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Medicine(all)
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Liver, lung, kidney and spleen macrophages in rats after intravenous administration of the modified magnetite nanoparticles. / Mil'to, I. V.
In: Morfologii{combining double inverted breve}a (Saint Petersburg, Russia), Vol. 146, No. 5, 2014, p. 40-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liver, lung, kidney and spleen macrophages in rats after intravenous administration of the modified magnetite nanoparticles
AU - Mil'to, I. V.
PY - 2014
Y1 - 2014
N2 - Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.
AB - Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.
UR - http://www.scopus.com/inward/record.url?scp=84928291596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928291596&partnerID=8YFLogxK
M3 - Article
VL - 146
SP - 40
EP - 45
JO - Arkhiv Anatomii, Gistologii i Embriologii
JF - Arkhiv Anatomii, Gistologii i Embriologii
SN - 1026-3543
IS - 5
ER -