Liver, lung, kidney and spleen macrophages in rats after intravenous administration of the modified magnetite nanoparticles

Abstract

Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Morfologii{combining double inverted breve}a (Saint Petersburg, Russia)
Volume	146
Issue number	5
Publication status	Published - 2014

ASJC Scopus subject areas

Medicine(all)

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title = "Liver, lung, kidney and spleen macrophages in rats after intravenous administration of the modified magnetite nanoparticles",

abstract = "Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.",

author = "Mil'to, {I. V.}",

year = "2014",

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AB - Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.

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