[Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration].

I. V. Mil'to, A. N. Dziuman

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.

    Original languageEnglish
    Pages (from-to)63-66
    Number of pages4
    JournalMorfologiia (Saint Petersburg, Russia)
    Volume135
    Issue number3
    Publication statusPublished - 2009

    Fingerprint

    Intravenous Administration
    Kidney
    Intravenous Injections
    Nanoparticles
    Lung
    Liver
    Mononuclear Phagocyte System
    Hematoxylin
    Eosine Yellowish-(YS)
    Necrosis
    Hemodynamics
    Ions

    ASJC Scopus subject areas

    • Histology
    • Pathology and Forensic Medicine

    Cite this

    [Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration]. / Mil'to, I. V.; Dziuman, A. N.

    In: Morfologiia (Saint Petersburg, Russia), Vol. 135, No. 3, 2009, p. 63-66.

    Research output: Contribution to journalArticle

    @article{53b9f78e562d4527931c4d50b3d3d854,
    title = "[Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration].",
    abstract = "This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.",
    author = "Mil'to, {I. V.} and Dziuman, {A. N.}",
    year = "2009",
    language = "English",
    volume = "135",
    pages = "63--66",
    journal = "Arkhiv Anatomii, Gistologii i Embriologii",
    issn = "1026-3543",
    publisher = "Morfologiya",
    number = "3",

    }

    TY - JOUR

    T1 - [Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration].

    AU - Mil'to, I. V.

    AU - Dziuman, A. N.

    PY - 2009

    Y1 - 2009

    N2 - This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.

    AB - This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.

    UR - http://www.scopus.com/inward/record.url?scp=79958167499&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79958167499&partnerID=8YFLogxK

    M3 - Article

    VL - 135

    SP - 63

    EP - 66

    JO - Arkhiv Anatomii, Gistologii i Embriologii

    JF - Arkhiv Anatomii, Gistologii i Embriologii

    SN - 1026-3543

    IS - 3

    ER -