Abstract
This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.
| Original language | English |
|---|---|
| Pages (from-to) | 63-66 |
| Number of pages | 4 |
| Journal | Morfologiia (Saint Petersburg, Russia) |
| Volume | 135 |
| Issue number | 3 |
| Publication status | Published - 2009 |
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ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
Cite this
[Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration]. / Mil'to, I. V.; Dziuman, A. N.
In: Morfologiia (Saint Petersburg, Russia), Vol. 135, No. 3, 2009, p. 63-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - [Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration].
AU - Mil'to, I. V.
AU - Dziuman, A. N.
PY - 2009
Y1 - 2009
N2 - This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.
AB - This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.
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UR - http://www.scopus.com/inward/citedby.url?scp=79958167499&partnerID=8YFLogxK
M3 - Article
VL - 135
SP - 63
EP - 66
JO - Arkhiv Anatomii, Gistologii i Embriologii
JF - Arkhiv Anatomii, Gistologii i Embriologii
SN - 1026-3543
IS - 3
ER -