Lithium-based antioxidants

Electrochemical properties and influence on immune cells

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Lithium salts are known as effective psychotropic medicine for treatment bipolar disorder and may be used to treat alcoholism, schizoaffective disorders, and cluster headaches. The antioxidant activity and immunomodulatory effects of prospective lithium compounds have been investigated in this work. Materials and Methods: The antioxidant properties were studied by the voltammetry method. Influence of the lithium compounds on the immune cells of human blood were determined by measuring phagocytic activity of leucocytes and by the rate of blastic transformation of lymphocytes. Results: Relatively better antioxidant and immunotropic properties have been revealed for lithium ascorbate, compare to widely used drug-lithium carbonate. Lithium aspartate revealed antioxidant activity, as well. Conclusion: Studied lithium salts can be considered as prospective psychotropic antioxidant with immunomodulatory effects. The combination of these properties significantly extends the potential medical applications of lithium salts.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalPhysiology and Pharmacology
Volume19
Issue number2
Publication statusPublished - 1 Jun 2015

Fingerprint

Lithium
Antioxidants
Lithium Compounds
Salts
alcoholism
Lithium Carbonate
Cluster Headache
medicine
drug
Lymphocyte Activation
Bipolar Disorder
Aspartic Acid
Psychotic Disorders
Alcoholism
Blood Cells
Leukocytes
Salt
Cells
Pharmaceutical Preparations

Keywords

  • Antioxidant activity
  • Immunomodulatory effects
  • Lithium ascorbate
  • Lithium aspartate
  • Voltammetry

ASJC Scopus subject areas

  • Pharmacology
  • Physiology

Cite this

Lithium-based antioxidants : Electrochemical properties and influence on immune cells. / Plotnikov, Evgenii; Korotkova, Elena; Voronova, Olesya Alexandrovna; Dorozhko, Elena; Bohan, Nikolay; Plotnikov, Sergey.

In: Physiology and Pharmacology, Vol. 19, No. 2, 01.06.2015, p. 107-113.

Research output: Contribution to journalArticle

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AU - Bohan, Nikolay

AU - Plotnikov, Sergey

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