Liposomes loaded with hydrophilic magnetite nanoparticles: Preparation and application as contrast agents for magnetic resonance imaging

S. V. German, N. A. Navolokin, N. R. Kuznetsova, V. V. Zuev, O. A. Inozemtseva, A. A. Anis'kov, E. K. Volkova, A. B. Bucharskaya, G. N. Maslyakova, R. F. Fakhrullin, G. S. Terentyuk, E. L. Vodovozova, D. A. Gorin

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Magnetic fluid-loaded liposomes (MFLs) were fabricated using magnetite nanoparticles (MNPs) and natural phospholipids via the thin film hydration method followed by extrusion. The size distribution and composition of MFLs were studied using dynamic light scattering and spectrophotometry. The effective ranges of magnetite concentration in MNPs hydrosol and MFLs for contrasting at both T2 and T1 relaxation were determined. On T2 weighted images, the MFLs effectively increased the contrast if compared with MNPs hydrosol, while on T1 weighted images, MNPs hydrosol contrasting was more efficient than that of MFLs. In vivo magnetic resonance imaging (MRI) contrasting properties of MFLs and their effects on tumor and normal tissues morphology, were investigated in rats with transplanted renal cell carcinoma upon intratumoral administration of MFLs. No significant morphological changes in rat internal organs upon intratumoral injection of MFLs were detected, suggesting that the liposomes are relatively safe and can be used as the potential contrasting agents for MRI.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume135
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

Keywords

  • Contrast agent
  • In vivo contrasting
  • Magnetic liposomes
  • Magnetic resonance imaging
  • Magnetite nanoparticles

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

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