Light-activated polymethylmethacrylate nanofibers with antibacterial activity

Roman Elashnikov, Oleksiy Lyutakov, Pavel Ulbrich, Vaclav Svorcik

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The creation of an antibacterial material with triggerable properties enables us to avoid the overuse or misuse of antibacterial substances and, thus, prevent the emergence of resistant bacterial strains. As a potential light-activated antibacterial material, polymethylmethacrylate (PMMA) nanofibers doped with silver nanoparticles (AgNPs) and meso-tetraphenylporphyrin (TPP) were prepared by electrospinning. TPP was chosen as an effectively reactive oxygen species (ROS) producer. Antibacterial tests on Staphylococcus epidermidis (S. epidermidis) and Enterococcus faecalis (E. faecalis) showed the excellent light-triggerable antibacterial activity of the doped materials. Upon light irradiation at the wavelength corresponding to the TPP absorption peak (405 nm), antibacterial activity dramatically increased, mostly due to the release of AgNPs from the polymer matrix. Furthermore, under prolonged light irradiation, the AgNPs/TPP/PMMA nanofibers, displayed enhanced longevity and photothermal stability. Thus, our results suggest that the proposed material is a promising option for the photodynamic inactivation of bacteria.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalMaterials Science and Engineering C
Volume64
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Fingerprint

Polymethyl Methacrylate
Nanofibers
Irradiation
irradiation
staphylococcus
Electrospinning
Polymer matrix
Silver
deactivation
bacteria
Reactive Oxygen Species
Bacteria
silver
Nanoparticles
Wavelength
nanoparticles
Oxygen
tetraphenylporphyrin
polymers
oxygen

Keywords

  • Antibacterial
  • Light-activated
  • Polymethylmethacrylate
  • Silver nanoparticle
  • Triggerable release

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Light-activated polymethylmethacrylate nanofibers with antibacterial activity. / Elashnikov, Roman; Lyutakov, Oleksiy; Ulbrich, Pavel; Svorcik, Vaclav.

In: Materials Science and Engineering C, Vol. 64, 01.07.2016, p. 229-235.

Research output: Contribution to journalArticle

Elashnikov, Roman ; Lyutakov, Oleksiy ; Ulbrich, Pavel ; Svorcik, Vaclav. / Light-activated polymethylmethacrylate nanofibers with antibacterial activity. In: Materials Science and Engineering C. 2016 ; Vol. 64. pp. 229-235.
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