Level of Interleukins IL-6 and IL-15 in Blood Plasma of Mice after Forced Swimming Test

Abstract

We measured the concentrations of IL-6 and IL-15 in blood plasma of mice at different terms after forced swimming, taking into account exercise intensity and preliminary training. It was shown that training was an important factor affecting blood plasma level of IL both at rest and after single forced swimming: in trained animals, the concentration of both myokines increased immediately after swimming, while in untrained animals, this increase was observed only after 5 h. Changes in cytokine production against the background of training can be associated with various factors, including neuroendocrine mechanisms, stress, modification of intracellular signaling, as well as reorganization of transcriptional mechanisms in muscle fibers. The most important factor is shift in the ratio of monovalent cations (sodium and potassium) in the cytoplasm.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
DOIs	https://doi.org/10.1007/s10517-017-3725-y
Publication status	Accepted/In press - 3 Jun 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-017-3725-y

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Kapilevich, L. V., Kironenko, T. A., Zakharova, A. N., Kabachkova, A. V., & Orlov, S. N. (Accepted/In press). Level of Interleukins IL-6 and IL-15 in Blood Plasma of Mice after Forced Swimming Test. Bulletin of Experimental Biology and Medicine, 1-4. https://doi.org/10.1007/s10517-017-3725-y

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title = "Level of Interleukins IL-6 and IL-15 in Blood Plasma of Mice after Forced Swimming Test",

abstract = "We measured the concentrations of IL-6 and IL-15 in blood plasma of mice at different terms after forced swimming, taking into account exercise intensity and preliminary training. It was shown that training was an important factor affecting blood plasma level of IL both at rest and after single forced swimming: in trained animals, the concentration of both myokines increased immediately after swimming, while in untrained animals, this increase was observed only after 5 h. Changes in cytokine production against the background of training can be associated with various factors, including neuroendocrine mechanisms, stress, modification of intracellular signaling, as well as reorganization of transcriptional mechanisms in muscle fibers. The most important factor is shift in the ratio of monovalent cations (sodium and potassium) in the cytoplasm.",

author = "Kapilevich, {L. V.} and Kironenko, {T. A.} and Zakharova, {A. N.} and Kabachkova, {A. V.} and Orlov, {S. N.}",

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AU - Kapilevich, L. V.

AU - Kironenko, T. A.

AU - Zakharova, A. N.

AU - Kabachkova, A. V.

AU - Orlov, S. N.

PY - 2017/6/3

Y1 - 2017/6/3

N2 - We measured the concentrations of IL-6 and IL-15 in blood plasma of mice at different terms after forced swimming, taking into account exercise intensity and preliminary training. It was shown that training was an important factor affecting blood plasma level of IL both at rest and after single forced swimming: in trained animals, the concentration of both myokines increased immediately after swimming, while in untrained animals, this increase was observed only after 5 h. Changes in cytokine production against the background of training can be associated with various factors, including neuroendocrine mechanisms, stress, modification of intracellular signaling, as well as reorganization of transcriptional mechanisms in muscle fibers. The most important factor is shift in the ratio of monovalent cations (sodium and potassium) in the cytoplasm.

AB - We measured the concentrations of IL-6 and IL-15 in blood plasma of mice at different terms after forced swimming, taking into account exercise intensity and preliminary training. It was shown that training was an important factor affecting blood plasma level of IL both at rest and after single forced swimming: in trained animals, the concentration of both myokines increased immediately after swimming, while in untrained animals, this increase was observed only after 5 h. Changes in cytokine production against the background of training can be associated with various factors, including neuroendocrine mechanisms, stress, modification of intracellular signaling, as well as reorganization of transcriptional mechanisms in muscle fibers. The most important factor is shift in the ratio of monovalent cations (sodium and potassium) in the cytoplasm.

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