Abstract
In solution, [Ln(H2O)n(dtpa)]2− chelates undergo a dynamic exchange between two enantiomers. The free energy of activation of intramolecular dynamics (for complexes of Pr to Ho) slightly increases with decreasing radius of the lanthanide cation. According to analysis of the paramagnetic lanthanide induced shifts (LIS) in NMR spectra, the structure of [Ho(H2O)n(dtpa)]2− in solution is similar to the related model found in the crystal state. It was found that complexes [Ln(H2O)n(dtpa)]2− may be used (due to the substantial temperature dependence of LIS) as NMR thermometric sensors for controlling the local temperature in aqueous medium. The investigated coordination compounds are suggested to apply as thermo-sensing contrast reagent for MRI diagnostics of cancer and inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 108-111 |
| Number of pages | 4 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 251 |
| DOIs | |
| Publication status | Published - 1 Nov 2017 |
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Keywords
- Conformation dynamics
- DTPA
- Free energy of activation
- Lanthanide complexes
- Lanthanide-induced shifts in NMR spectra
- NMR/MRI temperature sensor
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
- Electrical and Electronic Engineering
Cite this
Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lanthanides as NMR/MRI temperature sensors and probes of moderately fast molecular dynamics in aqueous medium
T2 - A dependence of activation energy of racemization in complexes of diethylenetriaminepentaacetat on lanthanide ion
AU - Babailov, Sergey P.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - In solution, [Ln(H2O)n(dtpa)]2− chelates undergo a dynamic exchange between two enantiomers. The free energy of activation of intramolecular dynamics (for complexes of Pr to Ho) slightly increases with decreasing radius of the lanthanide cation. According to analysis of the paramagnetic lanthanide induced shifts (LIS) in NMR spectra, the structure of [Ho(H2O)n(dtpa)]2− in solution is similar to the related model found in the crystal state. It was found that complexes [Ln(H2O)n(dtpa)]2− may be used (due to the substantial temperature dependence of LIS) as NMR thermometric sensors for controlling the local temperature in aqueous medium. The investigated coordination compounds are suggested to apply as thermo-sensing contrast reagent for MRI diagnostics of cancer and inflammation.
AB - In solution, [Ln(H2O)n(dtpa)]2− chelates undergo a dynamic exchange between two enantiomers. The free energy of activation of intramolecular dynamics (for complexes of Pr to Ho) slightly increases with decreasing radius of the lanthanide cation. According to analysis of the paramagnetic lanthanide induced shifts (LIS) in NMR spectra, the structure of [Ho(H2O)n(dtpa)]2− in solution is similar to the related model found in the crystal state. It was found that complexes [Ln(H2O)n(dtpa)]2− may be used (due to the substantial temperature dependence of LIS) as NMR thermometric sensors for controlling the local temperature in aqueous medium. The investigated coordination compounds are suggested to apply as thermo-sensing contrast reagent for MRI diagnostics of cancer and inflammation.
KW - Conformation dynamics
KW - DTPA
KW - Free energy of activation
KW - Lanthanide complexes
KW - Lanthanide-induced shifts in NMR spectra
KW - NMR/MRI temperature sensor
UR - http://www.scopus.com/inward/record.url?scp=85019498873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019498873&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2017.05.033
DO - 10.1016/j.snb.2017.05.033
M3 - Article
AN - SCOPUS:85019498873
VL - 251
SP - 108
EP - 111
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -