Lanthanide paramagnetic probes for NMR spectroscopic studies of molecular conformational dynamics in solution

Applications to macrocyclic molecules

S. P. Babailov

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

A study was conducted to demonstrate the application of lanthanide paramagnetic probes for nuclear magnetic resonance spectroscopic studies of molecular conformational dynamics in solution to macrocyclic molecules. It was found that lanthanide complexes in solution exhibited a well-defined luminescence, which was characterized by narrow emission bands, large Stokes' shifts, and long excited-state lifetimes. A number of NMR investigations of intramolecular dynamics for lanthanide complexes in aqueous solutions, with other macrocyclic ligands were also considered for comparison. The methodology of paramagnetic Ce, Nd, Pr, Eu, Dy, and Yb probe applications for studying the enthalpy and entropy changes in chemical exchange processes was also investigated. The advantages of the methodology in comparison with DNMR studies of diamagnetic substances were also demonstrated.

Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
Volume52
Issue number1
DOIs
Publication statusPublished - 30 Jan 2008
Externally publishedYes

Fingerprint

Lanthanoid Series Elements
Molecular Dynamics Simulation
Molecular dynamics
Nuclear magnetic resonance
methodology
molecular dynamics
nuclear magnetic resonance
Molecules
probes
Chemical Phenomena
molecules
enthalpy
Entropy
entropy
luminescence
Luminescence
aqueous solutions
Excited states
life (durability)
ligands

Keywords

  • DOTA-like ligands
  • Dynamic NMR spectroscopy
  • Lanthanide-induced shifts
  • Lanthanides
  • Macrocyclic polyethers
  • NMR lineshape
  • Nuclear Overhauser effect
  • Porphyrins
  • Selective magnetization transfer
  • Spin saturation transfer
  • Spin-lattice relaxation

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

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abstract = "A study was conducted to demonstrate the application of lanthanide paramagnetic probes for nuclear magnetic resonance spectroscopic studies of molecular conformational dynamics in solution to macrocyclic molecules. It was found that lanthanide complexes in solution exhibited a well-defined luminescence, which was characterized by narrow emission bands, large Stokes' shifts, and long excited-state lifetimes. A number of NMR investigations of intramolecular dynamics for lanthanide complexes in aqueous solutions, with other macrocyclic ligands were also considered for comparison. The methodology of paramagnetic Ce, Nd, Pr, Eu, Dy, and Yb probe applications for studying the enthalpy and entropy changes in chemical exchange processes was also investigated. The advantages of the methodology in comparison with DNMR studies of diamagnetic substances were also demonstrated.",
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T2 - Applications to macrocyclic molecules

AU - Babailov, S. P.

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N2 - A study was conducted to demonstrate the application of lanthanide paramagnetic probes for nuclear magnetic resonance spectroscopic studies of molecular conformational dynamics in solution to macrocyclic molecules. It was found that lanthanide complexes in solution exhibited a well-defined luminescence, which was characterized by narrow emission bands, large Stokes' shifts, and long excited-state lifetimes. A number of NMR investigations of intramolecular dynamics for lanthanide complexes in aqueous solutions, with other macrocyclic ligands were also considered for comparison. The methodology of paramagnetic Ce, Nd, Pr, Eu, Dy, and Yb probe applications for studying the enthalpy and entropy changes in chemical exchange processes was also investigated. The advantages of the methodology in comparison with DNMR studies of diamagnetic substances were also demonstrated.

AB - A study was conducted to demonstrate the application of lanthanide paramagnetic probes for nuclear magnetic resonance spectroscopic studies of molecular conformational dynamics in solution to macrocyclic molecules. It was found that lanthanide complexes in solution exhibited a well-defined luminescence, which was characterized by narrow emission bands, large Stokes' shifts, and long excited-state lifetimes. A number of NMR investigations of intramolecular dynamics for lanthanide complexes in aqueous solutions, with other macrocyclic ligands were also considered for comparison. The methodology of paramagnetic Ce, Nd, Pr, Eu, Dy, and Yb probe applications for studying the enthalpy and entropy changes in chemical exchange processes was also investigated. The advantages of the methodology in comparison with DNMR studies of diamagnetic substances were also demonstrated.

KW - DOTA-like ligands

KW - Dynamic NMR spectroscopy

KW - Lanthanide-induced shifts

KW - Lanthanides

KW - Macrocyclic polyethers

KW - NMR lineshape

KW - Nuclear Overhauser effect

KW - Porphyrins

KW - Selective magnetization transfer

KW - Spin saturation transfer

KW - Spin-lattice relaxation

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