Lanthanide paramagnetic probes for NMR spectroscopic studies of molecular conformational dynamics in solution: Applications to macrocyclic molecules

S. P. Babailov

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

A study was conducted to demonstrate the application of lanthanide paramagnetic probes for nuclear magnetic resonance spectroscopic studies of molecular conformational dynamics in solution to macrocyclic molecules. It was found that lanthanide complexes in solution exhibited a well-defined luminescence, which was characterized by narrow emission bands, large Stokes' shifts, and long excited-state lifetimes. A number of NMR investigations of intramolecular dynamics for lanthanide complexes in aqueous solutions, with other macrocyclic ligands were also considered for comparison. The methodology of paramagnetic Ce, Nd, Pr, Eu, Dy, and Yb probe applications for studying the enthalpy and entropy changes in chemical exchange processes was also investigated. The advantages of the methodology in comparison with DNMR studies of diamagnetic substances were also demonstrated.

Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
Volume52
Issue number1
DOIs
Publication statusPublished - 30 Jan 2008
Externally publishedYes

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Keywords

  • DOTA-like ligands
  • Dynamic NMR spectroscopy
  • Lanthanide-induced shifts
  • Lanthanides
  • Macrocyclic polyethers
  • NMR lineshape
  • Nuclear Overhauser effect
  • Porphyrins
  • Selective magnetization transfer
  • Spin saturation transfer
  • Spin-lattice relaxation

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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