Kinetic resolution by copper-catalyzed azide-alkyne cycloaddition

Jun Cai Meng, Valery V. Fokin, M. G. Finn

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


The use of chiral pybox ligands imparts enantioselectivity to the Cu I-catalyzed azide-alkyne cycloaddition reaction, in the form of kinetic resolution of α-chiral azides and desymmetrization of gem-diazides. While levels of selectivity are modest, the results show unequivocally that the process benefits from ligand-accelerated catalysis.

Original languageEnglish
Pages (from-to)4543-4546
Number of pages4
JournalTetrahedron Letters
Issue number27
Publication statusPublished - 4 Jul 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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