Abstract
The use of chiral pybox ligands imparts enantioselectivity to the Cu I-catalyzed azide-alkyne cycloaddition reaction, in the form of kinetic resolution of α-chiral azides and desymmetrization of gem-diazides. While levels of selectivity are modest, the results show unequivocally that the process benefits from ligand-accelerated catalysis.
Original language | English |
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Pages (from-to) | 4543-4546 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 27 |
DOIs | |
Publication status | Published - 4 Jul 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery