Ischemic postconditioning of the heart. Receptor mechanisms and possibility of clinical use

Yu B. Lishmanov, L. N. Maslov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The authors of the review have analyzed papers published during last six years on the problem of ischemic postconditioning of the heart. Postconditioning has been shown to decrease infarct size, prevent apoptosis of cardiomyocytes, improve cardiac contractility in reperfusion period, prevent appearance of reperfusion arrhythmias, prevent development of no-reflow phenomenon. Analyzes of published data demonstrate that adenosine, endogenous opioids, bradykinin, calcitonin gene-related peptide may be triggers of postconditioning. Data on successful use of postconditioning in patients with acute myocardial infarction and cardiac surgery patients are also presented and possibility of clinical use of adenosine receptor agonists and opioids is discussed.

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalKardiologiya
Volume50
Issue number6
Publication statusPublished - 2010

    Fingerprint

Keywords

  • Heart
  • Ischemic postconditioning
  • Myocardial infarction
  • Receptors
  • Trigger factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this