Iron oxide and gold nanoparticles in cancer therapy

Irena Gotman, Sergey G. Psakhie, Aleksandr S. Lozhkomoev, Elazar Y. Gutmanas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Continuous research activities in the field of nanomedicine in the past decade have, to a great extent, been focused on nanoparticle technologies for cancer therapy. Gold and iron oxide nanoparticles (NP) are two of the most studied inorganic nanomaterials due to their unique optical and magnetic properties. Both types of NPs are emerging as promising systems for anti-tumor drug delivery and for nanoparticle-mediated thermal therapy of cancer. In thermal therapy, localized heating inside tumors or in proximity of tumor cells can be induced, for example, with Au NPs by radiofrequency ablation heating or conversion of photon energy (photothermal therapy) and in iron oxide magnetic NPs by heat generation through relaxation in an alternating magnetic field (magnetic hyperthermia). Furthermore, the superparamagnetic properties of iron oxide nanoparticles have led to their use as potent MRI (magnetic resonance imaging) contrast agents. Surface modification/coating can produce NPs with tailored and desired properties, such as enhanced blood circulation time, stability, biocompatibility and water solubility. To target nanoparticles to specific tumor cells, NPs should be conjugated with targeting moieties on the surface which bind to receptors or other molecular structures on the cell surface. The article presents several approaches to enhancing the specificity of Au and iron oxide nanoparticles for tumor tissue by appropriate surface modification/functionalization, as well as the effect of these treatments on the saturation magnetization value of iron oxide NPs. The use of other nanoparticles and nanostructures in cancer treatment is also briefly reviewed.

Original languageEnglish
Title of host publicationPhysics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
PublisherAmerican Institute of Physics Inc.
Volume1760
ISBN (Electronic)9780735414181
DOIs
Publication statusPublished - 2 Aug 2016
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 - Tomsk, Russian Federation
Duration: 22 Mar 201625 Mar 2016

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016
CountryRussian Federation
CityTomsk
Period22.3.1625.3.16

Fingerprint

iron oxides
therapy
cancer
gold
nanoparticles
tumors
blood circulation
heating
oxides
hyperthermia
heat generation
biocompatibility
ablation
magnetic resonance
proximity
emerging
delivery
drugs
molecular structure
solubility

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Gotman, I., Psakhie, S. G., Lozhkomoev, A. S., & Gutmanas, E. Y. (2016). Iron oxide and gold nanoparticles in cancer therapy. In Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 (Vol. 1760). [020020] American Institute of Physics Inc.. https://doi.org/10.1063/1.4960239

Iron oxide and gold nanoparticles in cancer therapy. / Gotman, Irena; Psakhie, Sergey G.; Lozhkomoev, Aleksandr S.; Gutmanas, Elazar Y.

Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Vol. 1760 American Institute of Physics Inc., 2016. 020020.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gotman, I, Psakhie, SG, Lozhkomoev, AS & Gutmanas, EY 2016, Iron oxide and gold nanoparticles in cancer therapy. in Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. vol. 1760, 020020, American Institute of Physics Inc., International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016, Tomsk, Russian Federation, 22.3.16. https://doi.org/10.1063/1.4960239
Gotman I, Psakhie SG, Lozhkomoev AS, Gutmanas EY. Iron oxide and gold nanoparticles in cancer therapy. In Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Vol. 1760. American Institute of Physics Inc. 2016. 020020 https://doi.org/10.1063/1.4960239
Gotman, Irena ; Psakhie, Sergey G. ; Lozhkomoev, Aleksandr S. ; Gutmanas, Elazar Y. / Iron oxide and gold nanoparticles in cancer therapy. Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Vol. 1760 American Institute of Physics Inc., 2016.
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