Iron metabolism after application of modified magnetite nanoparticles in rats

I. V. Milto, A. Yu Grishanova, T. K. Klimenteva, I. V. Suhodolo, G. Yu Vasukov, V. V. Ivanova

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The influence of modified nanosized magnetite (NSM) particles (magnetic microspheres coated with chitosan and magnetoliposomes) after a single intravenous infusion of their suspensions on iron metabolism in rats has been studied. Modern physical and chemical methods (X-ray fluorescence, dynamic light scattering, transmission electron microscopy) were used for standardization of the modified NSM particles (their size, structure, ζ-potential, and concentration were determined). Atomic emission spectroscopy was used to reveal the dynamics of iron content in rat liver, spleen, lungs, and kidneys during 120 days. Colorimetric and immunoturbidimetric methods were used to determine the concentrations of plasma iron and the proteins involved in its metabolism - ceruloplasmin, transferrin, and ferritin. Their dynamics throughout the experiments were studied.

    Original languageEnglish
    Pages (from-to)1245-1254
    Number of pages10
    JournalBiochemistry (Moscow)
    Volume79
    Issue number11
    DOIs
    Publication statusPublished - 1 Jan 2014

    Keywords

    • Ceruloplasmin
    • Chitosan-modified nanomagnetite
    • Ferritin
    • Magnetoliposomes
    • Nanomagnetite
    • Transferrin

    ASJC Scopus subject areas

    • Biochemistry
    • Medicine(all)

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  • Cite this

    Milto, I. V., Grishanova, A. Y., Klimenteva, T. K., Suhodolo, I. V., Vasukov, G. Y., & Ivanova, V. V. (2014). Iron metabolism after application of modified magnetite nanoparticles in rats. Biochemistry (Moscow), 79(11), 1245-1254. https://doi.org/10.1134/S0006297914110121