Iodonium Salts as Benzyne Precursors

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33 Citations (Scopus)


Reactions involving benzyne and aryne intermediates have found widespread application in organic synthesis. Various benzyne precursors and benzyne generating procedures are known. Recently, methods of benzyne generation from diaryliodonium salts and related hypervalent iodine compounds have received considerable attention. These methods are characterized by mild reaction conditions and applicability in a broad range of chemical transformations. The present minireview is focused on the preparation and reactivity of hypervalent iodine based benzyne precursors. Furthermore, recent developments in their synthetic application are discussed.

Original languageEnglish
Pages (from-to)15156-15166
Number of pages11
JournalChemistry - A European Journal
Issue number57
Publication statusPublished - 12 Oct 2018


  • arynes
  • benzyne precursors
  • cycloaddition
  • hypervalent iodine
  • iodonium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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