Iodine(III)-Catalyzed Formal [2 + 2 + 1] Cycloaddition Reaction for Metal-Free Construction of Oxazoles

Takuma Yagyu, Yusuke Takemoto, Akira Yoshimura, Viktor V. Zhdankin, Akio Saito

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37 Citations (Scopus)


The iodine(III) catalyst, in situ generated from iodoarene as a precatalyst with m-CPBA and Tf2NH, promoted the metal-free [2 + 2 + 1] cycloaddition-type reactions of alkynes, nitriles, and oxygen atoms for the regioselective formations of 2,4-disubstituted and 2,4,5-trisubstituted oxazole. A first example of iodine catalysis for multicomponent reactions is represented.

Original languageEnglish
Pages (from-to)2506-2509
Number of pages4
JournalOrganic Letters
Issue number10
Publication statusPublished - 19 May 2017
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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