Iodination of aryl amines in a water-paste form via stable aryl diazonium tosylates

Dmitry A. Gorlushko, Victor D. Filimonov, Elena A. Krasnokutskaya, Nadya I. Semenischeva, Bong Seong Go, Ho Yun Hwang, Eun Hye Cha, Ki Whan Chi

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50 Citations (Scopus)

Abstract

The diazotization of aryl amines at room temperature in paste form with NaNO2, p-TsOH and a small amount of water, followed by treatment with KI provides a new, simple, and effective route for the preparation of various aryl iodides. The water-paste and strong acid-free reaction conditions are environmentally friendly and compatible with acid-sensitive functional groups.

Original languageEnglish
Pages (from-to)1080-1082
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number6
DOIs
Publication statusPublished - 4 Feb 2008

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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