Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries

Tatiana I. Spiridonova, Sergei I. Tverdokhlebov, Yuri G. Anissimov

Research output: Contribution to journalArticle

Abstract

Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when fitting the data leads to up to 5 times underestimation of the diffusion coefficient of drug in the polymer.

Original languageEnglish
JournalJournal of Pharmaceutical Sciences
DOIs
Publication statusPublished - 1 Jan 2019

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Drug Delivery Systems
Polymers
Modern 1601-history
Drug Liberation
Nanoparticles
Membranes
Pharmaceutical Preparations

Keywords

  • controlled drug release
  • diffusion
  • drug delivery systems
  • mathematical modeling
  • microparticles
  • nanoparticles

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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title = "Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries",
abstract = "Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when fitting the data leads to up to 5 times underestimation of the diffusion coefficient of drug in the polymer.",
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author = "Spiridonova, {Tatiana I.} and Tverdokhlebov, {Sergei I.} and Anissimov, {Yuri G.}",
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AU - Anissimov, Yuri G.

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