Investigation of the possibility to detect ventricular late potentials by a high-resolution electrocardiographic hardware-software complex based on nanosensors using Simson's method

Diana Konstantinovna Avdeeva, Maxim Leonidovich Ivanov, Sergey Anatol yevich Rybalka, Ivan Vadimovich Maksimov, Marija Vjacheslavovna Balahonova

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According to the World Health Organization (WHO), cardiovascular diseases (CVD) are the leading cause for death worldwide. Over the past 20 years, the effectiveness of sudden cardiac death (SCD) prevention has not virtually changed, so the development of new methods to identify the groups at risk of SCDs is of crucial importance. One of the promising directions to improve the method of electrocardiographic diagnostics of SCD signs is the development of tools that can measure the low-amplitude components of electrocardiosignal (ECS), the so-called micropotentials (MPs) of the heart. High-resolution hardware-software complex (HSC) based on nanosensors has been developed to record MPs of the heart in real time without filtering and averaging. The software component provides estimation of ECG low-amplitude components in order to detect early signs of SCD. The application of low-noise high-stability nonpolarizable noise-immune nanosensors enables the elimination of filters from the hardware. HSC is based on the algorithm of ventricular late potential (VLP) detection according to Simson's method both in the averaged signal (within 30 s) and single cardiac impulses. The article presents the results of high-resolution ECG processing according to Simson's method for a healthy person and for a patient who had undergone two heart attacks and heart failure. This high-resolution apparatus based on nanosensors will serve a high potential role in the ECG diagnostic rooms of the primary healthcare for the majority of patients.

Original languageEnglish
Article numberBM-129-15
JournalBiology and Medicine
Issue number4
Publication statusPublished - 2015



  • Hardware-software complex
  • High resolution
  • Micropotential
  • Nanosensor
  • Real time
  • Sudden cardiac death (SCD)
  • Ventricular late potentials (VLPs)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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