Investigation of new nsaids for the treatment of inflammatory diseases of kidney and urinary tract

Murashko Tatyana, Ivanov Alexey, Smirnov Ivan, Bondarev Alex, Alexey Nemtsev, Udut Vladimir

Research output: Contribution to journalArticle

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the world, primarily due to their high efficiency for the treatment of inflammatory induced pain syndrome. The main feature of NSAIDs is a combination of anti-inflammatory, analgesic, antipyretic, and anticoagulant properties. However, their long-term use is associated with side effects in the gastrointestinal tract including peptic ulcers and other. We developed and synthesized molecule of methyl (4-О-β-glucopyranosyloxy)-benzoic acid. The anti-inflammatory effect of methyl (4-О-β-glucopyranosyloxy)-benzoic acid evaluated using the carrageenan-induced hindpaw edema model. The study shows that the intragastrically administration of test substance to animals reduces inflammatory process.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalJurnal Teknologi
Volume78
Issue number5-6
DOIs
Publication statusPublished - 1 Jan 2016

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Keywords

  • Analgesic
  • Pain
  • Phenolic glycosides
  • Writhing test

ASJC Scopus subject areas

  • Engineering(all)

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