Abstract
Objective: Investigation of genotoxicity effects of the new antibacterial silver-based compound with of general formula [Ag (CH2)6 N4]+NO3 Methods: The comet assay applied for assessment of genotoxic effects on leukocytes of mice blood. DNA damage was assessed on the percentage of DNA in a comet tail (tail DNA), under influence of silver complex in different concentrations. . Results: During experiments found a significant increase in the level of DNA damage in cells, at the maximum tested concentrations. At low doses, the drug has no significant genotoxic effect. Conclusion: Tested silver complex did not cause DNA damage at low concentrations and could be considered as a base for new antibacterial drug.
| Original language | English |
|---|---|
| Pages (from-to) | 454-455 |
| Number of pages | 2 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 7 |
| Issue number | 7 |
| Publication status | Published - 2015 |
Keywords
- Antibacterial drug
- Comet assay
- Geno toxicity
- Silver hexa-methylene tetramine
- Silver-based complex
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
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Cite this
Plotnikov, E., Gapeyev, A., & Plotnikov, V. (2015). Investigation genotoxicity of new silver-based complexwith antimicrobial activity. International Journal of Pharmacy and Pharmaceutical Sciences, 7(7), 454-455.