Investigation genotoxicity of new silver-based complexwith antimicrobial activity

Evgenii Plotnikov, Andrew Gapeyev, Vladimir Plotnikov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Investigation of genotoxicity effects of the new antibacterial silver-based compound with of general formula [Ag (CH2)6 N4]+NO3 Methods: The comet assay applied for assessment of genotoxic effects on leukocytes of mice blood. DNA damage was assessed on the percentage of DNA in a comet tail (tail DNA), under influence of silver complex in different concentrations. . Results: During experiments found a significant increase in the level of DNA damage in cells, at the maximum tested concentrations. At low doses, the drug has no significant genotoxic effect. Conclusion: Tested silver complex did not cause DNA damage at low concentrations and could be considered as a base for new antibacterial drug.

Original languageEnglish
Pages (from-to)454-455
Number of pages2
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume7
Issue number7
Publication statusPublished - 2015

Keywords

  • Antibacterial drug
  • Comet assay
  • Geno toxicity
  • Silver hexa-methylene tetramine
  • Silver-based complex

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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