Abstract
Objective: Investigation of genotoxicity effects of the new antibacterial silver-based compound with of general formula [Ag (CH2)6 N4]+NO3 Methods: The comet assay applied for assessment of genotoxic effects on leukocytes of mice blood. DNA damage was assessed on the percentage of DNA in a comet tail (tail DNA), under influence of silver complex in different concentrations. . Results: During experiments found a significant increase in the level of DNA damage in cells, at the maximum tested concentrations. At low doses, the drug has no significant genotoxic effect. Conclusion: Tested silver complex did not cause DNA damage at low concentrations and could be considered as a base for new antibacterial drug.
| Original language | English |
|---|---|
| Pages (from-to) | 454-455 |
| Number of pages | 2 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 7 |
| Issue number | 7 |
| Publication status | Published - 2015 |
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Keywords
- Antibacterial drug
- Comet assay
- Geno toxicity
- Silver hexa-methylene tetramine
- Silver-based complex
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Investigation genotoxicity of new silver-based complexwith antimicrobial activity. / Plotnikov, Evgenii; Gapeyev, Andrew; Plotnikov, Vladimir.
In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, No. 7, 2015, p. 454-455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Investigation genotoxicity of new silver-based complexwith antimicrobial activity
AU - Plotnikov, Evgenii
AU - Gapeyev, Andrew
AU - Plotnikov, Vladimir
PY - 2015
Y1 - 2015
N2 - Objective: Investigation of genotoxicity effects of the new antibacterial silver-based compound with of general formula [Ag (CH2)6 N4]+NO3 Methods: The comet assay applied for assessment of genotoxic effects on leukocytes of mice blood. DNA damage was assessed on the percentage of DNA in a comet tail (tail DNA), under influence of silver complex in different concentrations. . Results: During experiments found a significant increase in the level of DNA damage in cells, at the maximum tested concentrations. At low doses, the drug has no significant genotoxic effect. Conclusion: Tested silver complex did not cause DNA damage at low concentrations and could be considered as a base for new antibacterial drug.
AB - Objective: Investigation of genotoxicity effects of the new antibacterial silver-based compound with of general formula [Ag (CH2)6 N4]+NO3 Methods: The comet assay applied for assessment of genotoxic effects on leukocytes of mice blood. DNA damage was assessed on the percentage of DNA in a comet tail (tail DNA), under influence of silver complex in different concentrations. . Results: During experiments found a significant increase in the level of DNA damage in cells, at the maximum tested concentrations. At low doses, the drug has no significant genotoxic effect. Conclusion: Tested silver complex did not cause DNA damage at low concentrations and could be considered as a base for new antibacterial drug.
KW - Antibacterial drug
KW - Comet assay
KW - Geno toxicity
KW - Silver hexa-methylene tetramine
KW - Silver-based complex
UR - http://www.scopus.com/inward/record.url?scp=84949746569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949746569&partnerID=8YFLogxK
M3 - Article
VL - 7
SP - 454
EP - 455
JO - International Journal of Pharmacy and Pharmaceutical Sciences
JF - International Journal of Pharmacy and Pharmaceutical Sciences
SN - 0975-1491
IS - 7
ER -