Interpretation of the Mössbauer spectra of the magnetic nanoparticles in mouse spleen

Mikhail A. Chuev, Valery M. Cherepanov, Sergey M. Deyev, Iliya N. Mischenko, Maxim P. Nikitin, Mikhail A. Polikarpov, Vladislav Y. Panchenko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)

Abstract

We have developed a stochastic model for description of relaxation effects in the system of homogeneously magnetized single-domain particles and applied the model to the analysis of Mössbauer spectra of magnetic nanoparticles (Chemicell ARA) and mouse spleen after i.v. injection into animals. We estimate that the fraction of exogenous iron in nanoparticles in the mouse spleen 3 months after injection was 0.27±0.03. The spectra of the residual nanoparticles in the spleen had almost the same isomer shift but smaller mean hyperfine magnetic field values indicating decrease in the magnetic anisotropy energy (size) of the particles compared to the initial ones in the course of biodegradation. Concentration of ferritin-like iron was about three-fold higher than that in the spleen of untreated animals showing ferritin-like forms in the mouse spleen.

Original languageEnglish
Title of host publication8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
Pages322-328
Number of pages7
Volume1311
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers - Rostock, Germany
Duration: 25 May 201029 May 2010

Conference

Conference8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
CountryGermany
CityRostock
Period25.5.1029.5.10

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Keywords

  • biodegradation
  • Magnetic nanoparticles
  • Mössbauer spectroscopy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Chuev, M. A., Cherepanov, V. M., Deyev, S. M., Mischenko, I. N., Nikitin, M. P., Polikarpov, M. A., & Panchenko, V. Y. (2010). Interpretation of the Mössbauer spectra of the magnetic nanoparticles in mouse spleen. In 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers (Vol. 1311, pp. 322-328) https://doi.org/10.1063/1.3530033