Interaction of tin(II) and arsenic(III) with DNA at the nanostructure film modified electrodes

Adriana Ferancová, Miriam Adamovski, Peter Gründler, Jiří Zima, Jiří Barek, Jürgen Mattusch, Rainer Wennrich, Ján Labuda

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Biosensors based on DNA and DNA-carbon nanotubes film immobilized at the surface of a screen-printed carbon electrode were used for simple in vitro tests of chemical toxicity. The damage to DNA caused by tin(II) and arsenic(III) compounds as components of specific reaction media was evaluated by means of an electrochemical DNA marker, [Co(phen)3]3+, as the portion of original dsDNA which survives an incubation of the biosensor in the cleavage medium. The results were confirmed by the electrically heated electrode and by the measurement of the DNA guanine moiety signal.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalBioelectrochemistry
Volume71
Issue number1
DOIs
Publication statusPublished - 1 Sep 2007
Externally publishedYes

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Keywords

  • Arsenic
  • DNA biosensor
  • DNA damage
  • Tin
  • Voltammetry

ASJC Scopus subject areas

  • Biophysics
  • Electrochemistry
  • Physical and Theoretical Chemistry

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